Tao M F, Sun D M, Shao H F, Li C B, Teng Y C
Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated to the Sixth People's Hospital, Shanghai, China.
Braz J Med Biol Res. 2016 Jan;49(1):e4718. doi: 10.1590/1414-431X20154718. Epub 2016 Nov 17.
Whether sleep problems of menopausal women are associated with vasomotor symptoms and/or changes in estrogen levels associated with menopause or age-related changes in sleep architecture is unclear. This study aimed to determine if poor sleep in middle-aged women is correlated with menopause. This study recruited women seeking care for the first time at the menopause outpatient department of our hospital. Inclusion criteria were an age ≥40 years, not taking any medications for menopausal symptoms, and no sleeping problems or depression. Patients were assessed with the Pittsburgh Sleep Quality Index (PSQI), modified Kupperman Index (KI), and Menopause Rating Scale (MRS). A PSQI score of <7 indicated no sleep disorder and ≥7 indicated a sleep disorder. Blood specimens were analyzed for follicle-stimulating hormone and estradiol levels. A total of 244 women were included in the study; 103 (42.2%) were identified as having a sleep disorder and 141 as not having one. In addition, 156 (64%) women were postmenopausal and 88 (36%) were not menopausal. Follicle-stimulating hormone and estradiol levels were similar between the groups. Patients with a sleep disorder had a significantly higher total modified KI score and total MRS score (both, P<0.001) compared with those without a sleep disorder. Correlations of the PSQI total score with the KI and MRS were similar in menopausal and non-menopausal women. These results do not support that menopause per se specifically contributes to sleep problems.
绝经后女性的睡眠问题是否与血管舒缩症状和/或与绝经相关的雌激素水平变化有关，还是与睡眠结构的年龄相关变化有关，目前尚不清楚。本研究旨在确定中年女性睡眠质量差是否与绝经有关。本研究招募了首次到我院绝经门诊就诊的女性。纳入标准为年龄≥40岁，未服用任何治疗绝经症状的药物，且无睡眠问题或抑郁症。患者接受匹兹堡睡眠质量指数（PSQI）、改良库珀曼指数（KI）和绝经评分量表（MRS）评估。PSQI评分<7表示无睡眠障碍，≥7表示有睡眠障碍。分析血标本中的促卵泡生成素和雌二醇水平。共有244名女性纳入本研究；其中103名（42.2%）被确定有睡眠障碍，141名无睡眠障碍。此外，156名（64%）女性已绝经，88名（36%）未绝经。两组之间促卵泡生成素和雌二醇水平相似。与无睡眠障碍的患者相比，有睡眠障碍的患者改良KI总分和MRS总分均显著更高（均P<0.001）。绝经和未绝经女性中，PSQI总分与KI和MRS的相关性相似。这些结果不支持绝经本身会导致睡眠问题这一观点。
