Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Analyst. 2020 May 21;145(10):3481-3489. doi: 10.1039/d0an00159g. Epub 2020 Apr 22.
Deoxyribonucleic acid (DNA), the carrier of genetic information in living life, is an essential biomacromolecule in almost all living systems. DNA has advantages including, programmability, predictability, high rigidity, and stability. Through self-assembly or combination with other nanomaterials (such as gold nanoparticles, graphene oxides, quantum dots, and polymers), DNA can be applied to construct specific, stable, biocompatible, and functional nanodevices. DNA nanodevices have made greater contributions in a plethora of fields. In this review, we discuss the recent progress of DNA nanodevices in molecular detection and analysis. Meanwhile, we prospect the development of various DNA devices in biological analysis, clinical diagnosis and biomedical research.
脱氧核糖核酸（DNA）是生物体内遗传信息的载体，是几乎所有生命系统中必不可少的生物大分子。DNA 具有可编程性、可预测性、高刚性和稳定性等优点。通过自组装或与其他纳米材料（如金纳米粒子、氧化石墨烯、量子点和聚合物）结合，DNA 可用于构建特定、稳定、生物相容和功能的纳米器件。DNA 纳米器件在众多领域做出了更大的贡献。在这篇综述中，我们讨论了 DNA 纳米器件在分子检测和分析方面的最新进展。同时，我们展望了各种 DNA 器件在生物分析、临床诊断和生物医学研究中的发展。
