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尼帕病毒:过去的疫情爆发和未来的控制。

Nipah Virus: Past Outbreaks and Future Containment.

机构信息

Virology Laboratory, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682022, Kerala, India.

出版信息

Viruses. 2020 Apr 20;12(4):465. doi: 10.3390/v12040465.

Abstract

Viral outbreaks of varying frequencies and severities have caused panic and havoc across the globe throughout history. Influenza, small pox, measles, and yellow fever reverberated for centuries, causing huge burden for economies. The twenty-first century witnessed the most pathogenic and contagious virus outbreaks of zoonotic origin including severe acute respiratory syndrome coronavirus (SARS-CoV), Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV) and Nipah virus. Nipah is considered one of the world's deadliest viruses with the heaviest mortality rates in some instances. It is known to cause encephalitis, with cases of acute respiratory distress turning fatal. Various factors contribute to the onset and spread of the virus. All through the infected zone, various strategies to tackle and enhance the surveillance and awareness with greater emphasis on personal hygiene has been formulated. This review discusses the recent outbreaks of Nipah virus in Malaysia, Bangladesh and India, the routes of transmission, prevention and control measures employed along with possible reasons behind the outbreaks, and the precautionary measures to be ensured by private-public undertakings to contain and ensure a lower incidence in the future.

摘要

历史上,各种频率和严重程度的病毒爆发在全球范围内引起了恐慌和混乱。流感、天花、麻疹和黄热病持续了几个世纪,给经济带来了巨大的负担。21 世纪见证了最具致病性和传染性的动物源病毒爆发,包括严重急性呼吸系统综合征冠状病毒(SARS-CoV)、埃博拉病毒、中东呼吸系统综合征冠状病毒(MERS-CoV)和尼帕病毒。尼帕被认为是世界上最致命的病毒之一,在某些情况下死亡率最高。它已知会引起脑炎,急性呼吸窘迫的病例会变得致命。各种因素导致了病毒的爆发和传播。在整个感染区,制定了各种应对策略,以加强监测和提高认识,更加注重个人卫生。本文讨论了马来西亚、孟加拉国和印度最近发生的尼帕病毒爆发、传播途径、所采取的预防和控制措施,以及爆发背后的可能原因,以及私营-公共企业为遏制病毒并确保未来发病率降低而应确保的预防措施。

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