Mohan Denesh, Khairullah Nur Fatin, How Yan Ping, Sajab Mohd Shaiful, Kaco Hatika
Research Center for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Polymers (Basel). 2020 Apr 23;12(4):986. doi: 10.3390/polym12040986.
Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO took place following the layer-by-layer films. The 3D printed double laminated CaCO-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner.
药物递送包括用于将药物化合物输送到体内特定区域以发挥安全治疗效果的制剂、技术和系统。选择正确的药物递送介质的主要标准是所携带药物的量以及释放药物所需的时间。因此，本研究旨在通过合成一种基于碳酸钙 - 纳米纤维素复合材料的介质并评估其作为药物递送介质的效率来改善上述标准。具体而言，根据5-氟尿嘧啶的摄取和释放速率评估效率。通过对合成复合材料的形态和化学性质的评估，按照逐层薄膜形成了纳米纤维素和碳酸钙既定的3D打印轮廓。3D打印的双层碳酸钙 - 纳米纤维素能够以有效的单一组合物并以时间控制的方式释放5-氟尿嘧啶。
