Faculdade de Medicina, Universidade José do Rosário Vellano, Alfenas, MG, Brasil.
Faculdade de Biomedicina, Universidade José do Rosário Vellano, Alfenas, MG, Brasil.
Braz J Med Biol Res. 2020;53(5):e9303. doi: 10.1590/1414-431x20209303. Epub 2020 Apr 27.
The control of dyslipidemia using plants is an important subject of studies since it has numerous benefits in cardiovascular protection. The objective of this study was to evaluate the effect of three Camellia sinensis L. teas (green, red, and white) on left ventricular hypertrophy and insulin resistance in low-density lipoprotein receptor knockout (LDLr-/-) mice fed a high-fat diet. The LDLr-/- mice were divided into four experimental groups: Group C: standard feed; Group CT: standard feed and three teas, Group HL: high-fat feed; HLT Group: high-fat feed and three teas. The three types of tea (green, red, and white) originated from different processing of the Camellia sinensis L. plant, and were administered associated once a day at a dose of 25 mg/kg by gavage for 60 days. The teas partially prevented hyperlipidemia, the decrease of the serum levels of high-density lipoproteins (HDL), insulin resistance, and increased C-reactive protein (CRP) levels, and completely prevented left ventricular hypertrophy in LDLr -/- mice of the HLT group. In conclusion, the three Camellia sinensis L. teas used to control genetic dyslipidemia associated with a high-fat diet can be used as an auxiliary treatment associated with the control of lipid intake, thus promoting cardiac protection against hyperlipidemia.
利用植物控制血脂异常是研究的重要课题，因为它在心血管保护方面有许多益处。本研究的目的是评估三种不同加工工艺的茶树（绿茶、红茶和白茶）对高脂饮食喂养的低密度脂蛋白受体敲除（LDLr-/-）小鼠左心室肥厚和胰岛素抵抗的影响。将 LDLr-/-小鼠分为四组实验：C 组：标准饲料；CT 组：标准饲料和三种茶；HL 组：高脂饲料；HLT 组：高脂饲料和三种茶。三种茶（绿茶、红茶和白茶）来自于不同加工工艺的茶树，每天通过灌胃给予 25mg/kg 的剂量，连续 60 天。茶部分预防了高脂血症、血清高密度脂蛋白（HDL）水平降低、胰岛素抵抗和 C 反应蛋白（CRP）水平升高，并完全预防了 HLT 组 LDLr-/-小鼠的左心室肥厚。综上所述，三种用于控制与高脂饮食相关的遗传性血脂异常的茶树茶可以作为辅助治疗方法与控制脂质摄入联合使用，从而促进心脏对高血脂的保护作用。
