Burke V, Stone D E, Beaman J, Gracey M
J Med Microbiol. 1977 May;10(2):241-4. doi: 10.1099/00222615-10-2-241.
Certain bile acids inhibit the growth in vitro of organisms commonly found in the intestine and, in particular, anaerobic bacteria. As the importance of this effect in vivo has not been demonstrated, we investigated changes in intestinal flora in the rat after diversion of bile to the urinary bladder. Five days after operation there was an increase in numbers of Proteus sp. in the stomach, mid-jejunum and caecum and of coliform bacilli in the stomach and mid-jejunum. Lacto-bacilli were increased in the stomach. There was no change in numbers of anaerobic organisms. Similar changes in bacterial flora followed 5 days of pair feeding in control rats. Our results do not suggest a specific antibacterial effect of bile salts in the rat in vivo. The changes found are probably related to semi-starvation, because the food intake of the rats after operation was about half that of control rats having an unrestricted diet.
某些胆汁酸可抑制肠道中常见微生物的体外生长，尤其是厌氧菌。由于这种作用在体内的重要性尚未得到证实，我们研究了将胆汁转至膀胱后大鼠肠道菌群的变化。术后5天，变形杆菌属在胃、空肠中部和盲肠中的数量增加，大肠埃希菌在胃和空肠中部的数量增加。胃中乳酸杆菌数量增加。厌氧菌数量没有变化。对照大鼠成对喂养5天后，细菌菌群也出现了类似变化。我们的结果并不表明胆汁盐在大鼠体内有特定的抗菌作用。所发现的变化可能与半饥饿状态有关，因为术后大鼠的食物摄入量约为饮食不受限制的对照大鼠的一半。
