Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Am J Med Sci. 2020 Jun;359(6):347-353. doi: 10.1016/j.amjms.2020.03.019. Epub 2020 Apr 5.
CD19IL-10B cells are considered as a particular subset of immunosuppressive cells by producing interleukin 10 (IL-10), which plays an important role in infectious and autoimmune diseases. The aim of this study was to determine the number of CD19IL-10B cells in Helicobacter pylori (H. pylori) positive patients in comparison with H. pylori negative patients, and to determine the association with different clinical outcomes, such as gastritis and peptic ulcer disease (PUD), in infected patients.
We studied 25 infected patients with gastritis, 25 infected patients with PUD, and 25 patients negative for H. pylori. The number of CD19IL-10B cells was determined by immunofluorescence.
The number of CD19IL-10B cells in patients infected with H. pylori was significantly 2.5-fold higher than uninfected patients (P < 0.0001). Also, the number of CD19IL-10B cells in infected patients with gastritis was significantly 1.45-fold elevated compared to infected patients with PUD (P = 0.001).
These results demonstrate that the increased number of CD19IL-10B cells in infected patients and its association with other cells may play an important role in the pathogenesis of H. pylori infection.
CD19IL-10B 细胞被认为是产生白细胞介素 10（IL-10）的免疫抑制细胞的特定亚群，在感染和自身免疫性疾病中发挥重要作用。本研究旨在确定与 H. pylori 阴性患者相比，H. pylori 阳性患者中 CD19IL-10B 细胞的数量，并确定其与感染患者不同临床结果（如胃炎和消化性溃疡病[PUD]）之间的关联。
我们研究了 25 例患有胃炎的感染患者、25 例患有 PUD 的感染患者和 25 例 H. pylori 阴性的患者。通过免疫荧光法测定 CD19IL-10B 细胞的数量。
感染 H. pylori 的患者中 CD19IL-10B 细胞的数量明显高于未感染的患者（P<0.0001）。此外，与患有 PUD 的感染患者相比，患有胃炎的感染患者中 CD19IL-10B 细胞的数量显著升高 1.45 倍（P=0.001）。
这些结果表明，感染患者中 CD19IL-10B 细胞数量的增加及其与其他细胞的关联可能在 H. pylori 感染的发病机制中发挥重要作用。
