聚合物-药物偶联物，一种对抗乳腺癌和肺癌的潜在疗法。

Alven Sibusiso, Nqoro Xhamla, Buyana Buhle, Aderibigbe Blessing A

Department of Chemistry, University of Fort Hare, Alice Eastern Cape 5700, South Africa.

Pharmaceutics. 2020 Apr 29;12(5):406. doi: 10.3390/pharmaceutics12050406.

Cancer is a chronic disease that is responsible for the high death rate, globally. The administration of anticancer drugs is one crucial approach that is employed for the treatment of cancer, although its therapeutic status is not presently satisfactory. The anticancer drugs are limited pharmacologically, resulting from the serious side effects, which could be life-threatening. Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. They transport therapeutic agents to the target cell/tissue. This review article is based on the therapeutic outcomes of polymer-drug conjugates against breast and lung cancer.

癌症是一种导致全球高死亡率的慢性疾病。抗癌药物的施用是用于治疗癌症的一种关键方法，尽管其目前的治疗状况并不令人满意。抗癌药物在药理学上存在局限性，这是由严重的副作用导致的，这些副作用可能会危及生命。聚合物药物偶联物、基于纳米的药物递送系统可用于保护正常身体组织免受抗癌药物的不良副作用影响，还可用于克服耐药性。它们将治疗剂输送到靶细胞/组织。这篇综述文章基于聚合物-药物偶联物对乳腺癌和肺癌的治疗效果。