Guo Xiaodong, Wen Fang, Zheng Nan, Saive Matthew, Fauconnier Marie-Laure, Wang Jiaqi
Key Laboratory of Quality & Safety Control for Milk and Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Chimie Générale et Organique, Gembloux Agro-Bio Tech, Université de Liège, Gembloux, Belgium.
Front Chem. 2020 Apr 21;8:195. doi: 10.3389/fchem.2020.00195. eCollection 2020.
Mycotoxins are a large type of secondary metabolites produced by fungi that pose a great hazard to and cause toxic reactions in humans and animals. A majority of countries and regulators, such as the European Union, have established a series of requirements for their use, and they have also set maximum tolerance levels. The development of high sensitivity and a specific analytical platform for mycotoxins is much in demand to address new challenges for food safety worldwide. Due to the superiority of simple, rapid, and low-cost characteristics, aptamer-based biosensors have successfully been developed for the detection of various mycotoxins with high sensitivity and selectivity compared with traditional instrumental methods and immunological approaches. In this article, we discuss and analyze the development of aptasensors for mycotoxins determination in food and agricultural products over the last 11 years and cover the literatures from the first report in 2008 until the present time. In addition, challenges and future trends for the selection of aptamers toward various mycotoxins and aptasensors for multi-mycotoxins analyses are summarized. Given the promising development and potential application of aptasensors, future research studies made will witness the great practicality of using aptamer-based biosensors within the field of food safety.
霉菌毒素是真菌产生的一大类次级代谢产物，对人类和动物具有极大危害并会引发毒性反应。大多数国家和监管机构，如欧盟，已针对其使用制定了一系列要求，还设定了最大耐受水平。为应对全球食品安全面临的新挑战，对高灵敏度和特异性的霉菌毒素分析平台需求迫切。基于适体的生物传感器具有简单、快速和低成本的优势，与传统仪器方法和免疫方法相比，已成功用于高灵敏度和高选择性地检测各种霉菌毒素。在本文中，我们讨论并分析了过去11年中用于食品和农产品中霉菌毒素测定的适体传感器的发展情况，涵盖了从2008年首次报道至今的文献。此外，还总结了针对各种霉菌毒素选择适体以及用于多霉菌毒素分析的适体传感器所面临的挑战和未来趋势。鉴于适体传感器的良好发展前景和潜在应用，未来的研究将见证基于适体的生物传感器在食品安全领域的巨大实用性。
