Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Molecules. 2020 May 5;25(9):2154. doi: 10.3390/molecules25092154.
(QM)-a member of the Fagaceae family-has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5α-reductase type 1 inhibitory activities compared with the PC, dutasteride.
（QM）-金缕梅科的一员-在韩国、中国和蒙古被用作传统药物，用于治疗口腔、生殖器或肛门黏膜的炎症和皮肤的外部炎症。为了治疗寻常痤疮（AV），我们评估了 QM 叶提取物（QML）及其主要化合物，漆树酸（PD）在体外和 5α-还原酶抑制活性中的抑制炎症细胞因子（IL-6 和 IL-8）的作用。结果表明，与阳性对照（PC）NG-单甲基-L-精氨酸（L-NMMA）相比，QML 和 PD 表现出很强的 NO 产生抑制活性。与 PC、表没食子儿茶素没食子酸酯（EGCG）相比，QML 和 PD 还显示出 IL-6 和 IL-8 的减少，并表现出比 PC、度他雄胺更强的 5α-还原酶 1 型抑制活性。
