Smith Louise E, Amlôt Richard, Weinman John, Yiend Jenny, Rubin G James
King's College London, Institute of Psychiatry, Psychology and Neuroscience, United Kingdom.
Public Health England, Emergency Response Department Science & Technology, Porton Down, United Kingdom.
Vaccine. 2020 Jun 2;38(27):4230-4235. doi: 10.1016/j.vaccine.2020.04.029. Epub 2020 May 5.
Child influenza vaccination rates for the UK are published annually, however there are no publicly available data on how many children are re-vaccinated the following year. This prospective cohort study aimed to identify factors associated with not re-vaccinating one's child. Participants (n = 270) completed a questionnaire before their child was vaccinated for influenza in the 2016/17 season, and follow-up questionnaires three days and one month after their child's vaccination. Re-vaccination data were collected at the end of the 2017/18 influenza season (n = 232, response rate 85.9%). Forty-one children (17.7%) were not re-vaccinated for influenza in 2017/18. Parental report of severe side-effects three days after vaccination (p = .04) and worry about side-effects one month after vaccination (p = .05) were associated with not re-vaccinating. However, the restricted sample size reduced the statistical power of these analyses. Decreasing parental worry about side-effects may help improve re-vaccination rates. Clinical trial registration: The study was registered on ClinicalTrials.gov (NCT02909855).
英国儿童流感疫苗接种率每年公布，但没有公开数据显示次年有多少儿童再次接种。这项前瞻性队列研究旨在确定与不给孩子再次接种疫苗相关的因素。参与者（n = 270）在其孩子于2016/17季节接种流感疫苗前完成一份问卷，并在孩子接种疫苗三天和一个月后完成随访问卷。在2017/18流感季节结束时收集再次接种数据（n = 232，应答率85.9%）。2017/18年有41名儿童（17.7%）未再次接种流感疫苗。接种疫苗三天后家长报告有严重副作用（p = 0.04）以及接种疫苗一个月后担心副作用（p = 0.05）与未再次接种有关。然而，样本量受限降低了这些分析的统计效力。减少家长对副作用的担忧可能有助于提高再次接种率。临床试验注册：该研究已在ClinicalTrials.gov（NCT02909855）上注册。
