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及其活性成分的抗黑色素生成作用：蛋白激酶A/环磷酸腺苷反应元件结合蛋白和p38丝裂原活化蛋白激酶介导的小眼畸形相关转录因子下调

Anti-Melanogenic Effect of and Its Active Components Protein Kinase A/Cyclic Adenosine Monophosphate-Responsive Binding Protein- and p38 Mitogen-Activated Protein Kinase-Mediated Microphthalmia-Associated Transcription Factor Downregulation.

作者信息

Park Jung Up, Yang Seo Young, Guo Rui Hong, Li Hong Xu, Kim Young Ho, Kim Young Ran

机构信息

College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, South Korea.

College of Pharmacy, Chungnam National University, Daejeon, South Korea.

出版信息

Front Pharmacol. 2020 Apr 23;11:507. doi: 10.3389/fphar.2020.00507. eCollection 2020.

DOI:10.3389/fphar.2020.00507
PMID:32390848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7191003/
Abstract

H. Lév has been reported to have some pharmacologic activities and also interested in functional cosmetics. We found that the water extract of leaves significantly inhibited tyrosinase activity and melanin formation in α-melanocyte stimulating hormone (MSH)-induced B16-F10 cells. reduced melanogenesis-related protein levels, such as microphthalmia-associated transcription factor (MITF), TRP-1, and TRP-2, without any cytotoxicity. Two active ingredients of (10E)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoate (DMW-1) and (10E)-(-)-10,17-octadecadiene-12,14-diyne-1,9,16-triol (DMW-2) were identified by testing the anti-melanogenic effects and then by liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis. DMW-1 and DMW-2 significantly inhibited melanogenesis by the suppression of protein kinase A (PKA)/cyclic AMP (cAMP)-responsive binding protein (CREB) and p38 MAPK phosphorylation. DMW-1 showed a better inhibitory effect than DMW-2 in α-MSH-induced B16-F10 cells. and its active component DMW-1 inhibited melanogenesis through the downregulation of cAMP, p-PKA/CREB, p-p38, MITF, TRP-1, TRP-2, and tyrosinase. These results indicate that and DMW-1 may be useful ingredients for cosmetics and therapeutic agents for skin hyperpigmentation disorders.

摘要

据报道，H. Lév具有一些药理活性，并且对功能性化妆品也有研究兴趣。我们发现，[植物名称]叶的水提取物能显著抑制α-黑素细胞刺激素（MSH）诱导的B16-F10细胞中的酪氨酸酶活性和黑色素生成。降低了与黑色素生成相关的蛋白质水平，如小眼畸形相关转录因子（MITF）、酪氨酸酶相关蛋白-1（TRP-1）和酪氨酸酶相关蛋白-2（TRP-2），且无任何细胞毒性。通过测试抗黑色素生成作用，然后进行液相色谱-串联质谱（LC/MS/MS）分析，鉴定出[植物名称]的两种活性成分，即（10E）-9,16-二羟基十八碳-10,17-二烯-12,14-二炔酸酯（DMW-1）和（10E）-（-）-10,17-十八碳二烯-12,14-二炔-1,9,16-三醇（DMW-2）。DMW-1和DMW-2通过抑制蛋白激酶A（PKA）/环磷酸腺苷（cAMP）反应结合蛋白（CREB）和p38丝裂原活化蛋白激酶（MAPK）的磷酸化，显著抑制黑色素生成。在α-MSH诱导的B16-F10细胞中，DMW-1的抑制作用优于DMW-2。[植物名称]及其活性成分DMW-1通过下调cAMP、磷酸化PKA/CREB、磷酸化p38、MITF、TRP-1、TRP-2和酪氨酸酶来抑制黑色素生成。这些结果表明，[植物名称]和DMW-1可能是用于化妆品和治疗皮肤色素沉着紊乱的治疗剂的有用成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/a7d69865195f/fphar-11-00507-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/2d82fe2becf6/fphar-11-00507-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/a7d69865195f/fphar-11-00507-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/b7dccd6b5bd0/fphar-11-00507-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/c69c4ed38840/fphar-11-00507-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/1948374a0491/fphar-11-00507-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/2d82fe2becf6/fphar-11-00507-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0497/7191003/a7d69865195f/fphar-11-00507-g007.jpg

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2
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3
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J Microbiol Biotechnol. 2024 Nov 28;34(11):2279-2289. doi: 10.4014/jmb.2408.08015. Epub 2024 Sep 30.
4
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5
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7
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