Pediatric Allergy Center, Istituto Giannina Gaslini, Genoa, Italy.
Pediatrics Clinic, Pediatrics Department, Policlinico San Matteo, University of Pavia, Pavia, Italy.
Allergol Immunopathol (Madr). 2021 Jan 2;49(1):32-39. doi: 10.15586/aei.v49i1.14. eCollection 2021.
Asthma control is the goal of asthma management. A nationwide study on this aspect was launched by the Italian Society of Paediatric Allergy and Immunology (ControL'Asma study).
To define variables associated with different asthma control grades in a nationwide population of asthmatic children and adolescents.
This cross-sectional real-world study included 480 asthmatic children and adolescents (333 males, median age 11.2 years) consecutively enrolled in 10 third level pediatric allergy clinics. According to the Global Initiative for Asthma (GINA) document, history, medication use, perception of asthma symptoms assessed by visual analog scale (VAS), clinical examination, lung function, childhood asthma control test (cACT)/asthma control test (ACT), and asthma control level were evaluated.
Considering GINA criteria, asthma was well controlled in 55% of patients, partly controlled in 32.4%, and uncontrolled in 12.6%. Regarding cACT/ACT, asthma was uncontrolled in 23.2%. Patients with uncontrolled asthma had the lowest lung function parameters and VAS scores, more frequent bronchial obstruction and reversibility, and used more oral and inhaled corticosteroids (CS).
The ControL'Asma study, performed in a real-world setting, showed that asthma in Italian children and adolescents was usually more frequent in males. Asthmatic patients had an early onset and allergic phenotype with very frequent rhinitis comorbidity. Uncontrolled and partly controlled asthma affected about half of the subjects, and the assessment of asthma symptom perception by VAS could be a reliable tool in asthma management.
哮喘控制是哮喘管理的目标。意大利儿童过敏与免疫学学会（ControL'Asma 研究）开展了一项全国性的哮喘控制研究。
确定与全国范围内哮喘儿童和青少年不同哮喘控制等级相关的变量。
这是一项横断面真实世界研究，纳入了 10 个三级儿科过敏诊所连续就诊的 480 例哮喘儿童和青少年（333 例男性，中位年龄 11.2 岁）。根据全球哮喘倡议（GINA）文件，评估了哮喘病史、药物使用、哮喘症状的视觉模拟量表（VAS）评分、临床检查、肺功能、儿童哮喘控制测试（cACT）/哮喘控制测试（ACT）和哮喘控制水平。
根据 GINA 标准，55%的患者哮喘得到良好控制，32.4%部分控制，12.6%未控制。根据 cACT/ACT，23.2%的哮喘未得到控制。未控制哮喘患者的肺功能参数和 VAS 评分最低，支气管阻塞和可逆性更频繁，且更多地使用口服和吸入性皮质类固醇（CS）。
在真实环境中进行的 ControL'Asma 研究表明，意大利儿童和青少年哮喘通常更常见于男性。哮喘患者有早期发病和过敏表型，且经常合并鼻炎。约一半的哮喘患者未得到控制或部分控制，VAS 评估哮喘症状感知可能是哮喘管理的可靠工具。
