肠道中的IgE产生细胞扩大了肠道在食物过敏中的作用。
IgE producers in the gut expand the gut's role in food allergy.
作者信息
Iweala Onyinye I, Burks A Wesley
机构信息
Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Pediatrics, University of North Carolina Food Allergy Initiative, Division of Allergy, Immunology and Rheumatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Nat Rev Gastroenterol Hepatol. 2020 Jul;17(7):384-386. doi: 10.1038/s41575-020-0309-5.
Abstract
Details about IgE-producing B cells in the gut in the context of food allergy are scarce, despite the frequent exposure of the gut and its associated lymphoid tissues to dietary antigens. A new study finds that IgE-producing B cells are enriched in gut tissues and are probably generated from local antibody isotype switching.
摘要
尽管肠道及其相关淋巴组织频繁接触饮食抗原，但关于食物过敏背景下肠道中产生IgE的B细胞的详细信息却很少。一项新研究发现，产生IgE的B细胞在肠道组织中富集，并且可能由局部抗体同种型转换产生。
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