Makizako Hyuma, Nakai Yuki, Tomioka Kazutoshi, Taniguchi Yoshiaki, Sato Nana, Wada Ayumi, Kiyama Ryoji, Tsutsumimoto Kota, Ohishi Mitsuru, Kiuchi Yuto, Kubozono Takuro, Takenaka Toshihiro
Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima 890-8544, Japan.
Graduate School of Health Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
J Clin Med. 2020 May 8;9(5):1386. doi: 10.3390/jcm9051386.
This study aimed to assess the effects of a multicomponent exercise program on physical function and muscle mass in older adults with sarcopenia or pre-sarcopenia. Moreover, we aim to standardize the exercise program for easy incorporation in the daily life of community-dwelling older adults as a secondary outcome. A single-blind randomized controlled trial was conducted with individuals (≥60 years) who had sarcopenia or pre-sarcopenia ( = 72). Participants were randomly assigned to the exercise and control groups. The exercise program consisted of 12 weekly 60-minute sessions that included resistance, balance, flexibility, and aerobic training. Outcome measures were physical function and muscle mass. Assessments were conducted before and immediately after the intervention. Among the 72 participants (mean age: 75.0 ± 6.9 years; 70.8% women), 67 (93.1%) completed the trial. Group-by-time interactions on the chair stand ( = 0.02) and timed "up and go" ( = 0.01) tests increased significantly in the exercise group. Although the exercise group showed a tendency to prevent loss of muscle mass, no significant interaction effects were observed for cross-sectional muscle area and muscle volume. The 12-week exercise program improved physical function in the intervention group. Although it is unclear whether the program is effective in increasing muscle mass, a multicomponent exercise program would be an effective treatment for physical function among older adults with sarcopenia.
本研究旨在评估多组分运动计划对患有肌肉减少症或肌肉减少症前期的老年人身体功能和肌肉量的影响。此外，作为次要结果，我们旨在规范该运动计划，以便于社区居住的老年人将其纳入日常生活。对患有肌肉减少症或肌肉减少症前期（n = 72）的≥60岁个体进行了单盲随机对照试验。参与者被随机分配到运动组和对照组。运动计划包括每周12次、每次60分钟的课程，内容包括阻力训练、平衡训练、柔韧性训练和有氧运动。结果指标为身体功能和肌肉量。在干预前和干预后立即进行评估。在72名参与者（平均年龄：75.0±6.9岁；70.8%为女性）中，67名（93.1%）完成了试验。运动组在椅子站立试验（P = 0.02）和定时起立行走试验（P = 0.01）中的组间时间交互作用显著增加。虽然运动组显示出防止肌肉量流失的趋势，但在横截面积和肌肉体积方面未观察到显著的交互作用。为期12周的运动计划改善了干预组的身体功能。虽然尚不清楚该计划是否能有效增加肌肉量，但多组分运动计划对于患有肌肉减少症的老年人的身体功能将是一种有效的治疗方法。
