Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia.
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia.
Int J Environ Res Public Health. 2020 May 8;17(9):3291. doi: 10.3390/ijerph17093291.
Information on the role of 25-hydroxyvitamin D (25(OH)D) in preventing adverse pregnancy/neonatal outcomes is limited in Malaysia. This study aims to determine the relationship between the level of maternal 25(OH)D in the first trimester of pregnant women and their pregnancy/neonatal outcomes. A total of 60 pregnant women in the first trimester were recruited and followed until the end of their pregnancy. The occurrence of any antenatal, delivery, and neonatal complications was recorded. Their blood was collected in the first trimester for total serum 25(OH)D determination using enzyme-linked immunosorbent assay. Overall, 10% of the women had vitamin D deficiency, while 57% had vitamin D insufficiency in their first trimester. No statistically significant difference in 25(OH)D level/status was observed between women with or without antenatal and delivery complications ( > 0.05). No difference in maternal serum 25(OH)D level and vitamin D status was observed between neonates with or without complications ( > 0.05). In conclusion, there is a high prevalence of vitamin D insufficiency among Malaysian pregnant women, but it is not associated with adverse maternal and neonatal outcomes. More comprehensive studies should be planned to verify this relationship.
马来西亚关于 25-羟维生素 D（25(OH)D）在预防不良妊娠/新生儿结局中的作用的信息有限。本研究旨在确定孕妇孕早期母体 25(OH)D 水平与妊娠/新生儿结局之间的关系。共招募了 60 名孕早期的孕妇，并随访至妊娠结束。记录了所有产前、分娩和新生儿并发症的发生情况。在孕早期采集这些孕妇的血液，使用酶联免疫吸附测定法测定总血清 25(OH)D。总体而言，10%的孕妇存在维生素 D 缺乏，57%的孕妇存在维生素 D 不足。在有或没有产前和分娩并发症的孕妇中，25(OH)D 水平/状态无统计学差异（>0.05）。在有或没有并发症的新生儿中，母体血清 25(OH)D 水平和维生素 D 状态无差异（>0.05）。综上所述，马来西亚孕妇维生素 D 不足的发生率较高，但与不良的母婴结局无关。应计划进行更全面的研究来验证这种关系。
