Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Brain Research Center, National Yang-Ming University, Taipei, Taiwan.
Cephalalgia. 2020 Sep;40(10):1104-1112. doi: 10.1177/0333102420923646. Epub 2020 May 12.
Headache disorders like migraine show geographic and ethnic differences between Asian and European/North American countries. In cluster headache, these differences are rarely mentioned and discussed. This article aimed to review the characteristics of cluster headache in Asian countries and compare the clinical features to those in European and North American populations.
We conducted a narrative literature review on the demographics, clinical presentations, and treatments of cluster headache in Asian countries.
Patients with cluster headache in Asian populations showed a stronger male predominance compared to European and North American populations. Chronic cluster headache was rare in Asian countries. The clinical presentation of restlessness was not as common in Asian as it was in European and North American countries, and Asian patients with aura were extremely rare. Patients in Asian countries may have a lower circadian rhythmicity of cluster headache and a lower headache load, as demonstrated by lower attack frequencies per day, bout frequencies, and bout durations.
Regional differences in the presentation of cluster headache exist. Greater awareness for cluster headache should be raised in Asian regions, and further studies are warranted to elucidate the mechanisms behind observed differences.
偏头痛等头痛障碍在亚洲和欧洲/北美国家之间存在地域和种族差异。在丛集性头痛中，这些差异很少被提及和讨论。本文旨在回顾亚洲国家丛集性头痛的特征，并将其临床特征与欧洲和北美人群进行比较。
我们对亚洲国家丛集性头痛的人口统计学、临床表现和治疗进行了叙述性文献回顾。
与欧洲和北美人群相比，亚洲人群的丛集性头痛患者中男性比例更高。慢性丛集性头痛在亚洲国家较为罕见。亚洲国家的不安表现不如欧洲和北美国家常见，而有先兆的亚洲患者极为罕见。亚洲国家的患者丛集性头痛的昼夜节律可能较低，头痛负担也较低，表现为每日发作频率、发作次数和发作持续时间较低。
丛集性头痛的表现存在区域性差异。亚洲地区应提高对丛集性头痛的认识，有必要进一步研究以阐明观察到的差异背后的机制。
