Programa de Pós-Graduação em Biotecnologia da Rede Renorbio, Universidade Federal do Maranhão, 65065-545 São Luís, Maranhão, Brazil.
Programa de Pós-Graduação em Biotecnologia da Rede Renorbio, Universidade Federal do Maranhão, 65065-545 São Luís, Maranhão, Brazil.
Acta Trop. 2020 Sep;209:105489. doi: 10.1016/j.actatropica.2020.105489. Epub 2020 May 11.
This review aims to describe essential oils with bioactivity on adult snails of the genera Bulinus and Biomphalaria, which are intermediate hosts of schistosomes, and brings together information relating to the importance of molluscicides and the chemical composition and toxicity of such oils for other aquatic species. Analysis of the data of original articles revealed that 50 essential oils obtained from 46 plant species were evaluated for molluscicidal activity against the genera cited. More than 80% of the volatile oils studied were active, according to the criteria of the World Health Organization (LC or LC ≤100 µg/mL or LC <40 µg/mL), and most of the oils came from plants belonging to the Rutaceae, Lamiaceae and Pinaceae. Around 37% of the surveyed plant species were obtained in Brazil and 88% of these plants were collected in the northeast of the country, a region with a high prevalence of schistosomiasis mansoni. The essential oils with the highest toxicity against host snails had high levels of hydrocarbon monoterpenes and oxygenated monoterpenes, which may be responsible for the molluscicidal activity. Some volatile components were subjected to molluscicidal evaluation, and the monoterpene compounds exhibited a significant molluscicide effect. This review confirmed the importance of essential oils as a promising alternative for the development of natural molluscicide products. However, in order to be safe for use at sites where schistosome intermediate hosts are found, information on ecotoxicity is required and, to date, few oils have been tested against non-target aquatic species.
本文旨在描述对布氏血属（Bulinus）和双腔属（Biomphalaria）成螺（血吸虫的中间宿主）具有生物活性的精油，并汇集了有关杀螺剂的重要性以及此类油对其他水生物种的化学成分和毒性的信息。对原始文章数据的分析表明，从 46 种植物中获得的 50 种精油已针对上述属的杀螺活性进行了评估。根据世界卫生组织（LC 或 LC ≤100 µg/mL 或 LC <40 µg/mL）的标准，超过 80%的挥发性油具有活性，研究中的大多数油都来自芸香科（Rutaceae）、唇形科（Lamiaceae）和松科（Pinaceae）的植物。约 37%的调查植物物种来自巴西，其中 88%的植物来自该国东北部，该地区曼氏血吸虫病流行率较高。对宿主蜗牛毒性最高的精油含有高水平的单萜烃和单萜氧化物，这可能是其杀螺活性的原因。一些挥发性成分已进行杀螺评估，单萜化合物表现出显著的杀螺效果。本综述证实了精油作为开发天然杀螺剂产品的有前途的替代物的重要性。然而，为了在发现血吸虫中间宿主的地方安全使用，需要有关生态毒性的信息，迄今为止，很少有油已针对非靶标水生物种进行测试。
