枯草芽孢杆菌中影响3-磷酸甘油转运的一个基因座的定位
Mapping of a genetic locus that affects glycerol 3-phosphate transport in Bacillus subtilis.
作者信息
Lindgren V
出版信息
J Bacteriol. 1978 Feb;133(2):667-70. doi: 10.1128/jb.133.2.667-670.1978.
Abstract
Two types of fosfomycin-resistant mutants of Bacillus subtilis were isolated. Mutants of the first type (GlpT mutants) were resistant to at least 200 microgram of fosfomycin per ml and failed to take up exogenous glycerol 3-phosphate. Mutants of the second type were resistant to lower concentrations of fosfomycin and transported glycerol-3-phosphate as efficiently as wild-type bacteria. The glpT mutations, but not the mutations in the second type of fosfomycin-resistant mutants, map in the cysA-aroI region of the B. subtilis chromosome.
摘要
分离出了两种枯草芽孢杆菌的磷霉素抗性突变体。第一类突变体（GlpT突变体）对每毫升至少200微克的磷霉素具有抗性，并且无法摄取外源甘油3-磷酸。第二类突变体对较低浓度的磷霉素具有抗性，并且转运甘油-3-磷酸的效率与野生型细菌相同。GlpT突变而非第二类磷霉素抗性突变体中的突变，定位在枯草芽孢杆菌染色体的cysA-aroI区域。
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