Hong KyungPyo, Collins Jeremy D, Freed Benjamin H, Fan Lexiaozi, Arai Andrew E, Hsu Li-Yueh, Lee Daniel C, Kim Daniel
Department of Radiology (K.P.H., L.F., D.K.) and Division of Cardiology, Department of Internal Medicine (B.H.F., D.C.L.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.E.A., L.Y.H.); and Department of Biomedical Engineering, Northwestern University, Evanston, Ill (L.F., D.K.).
Radiol Cardiothorac Imaging. 2020 Apr 16;2(2):e190114. doi: 10.1148/ryct.2020190114.
To develop an accelerated wideband cardiac perfusion pulse sequence and test whether it can produce diagnostically acceptable image quality and whether it can be used to reliably quantify myocardial blood flow (MBF) in patients with a cardiac implantable electronic device (CIED).
A fivefold-accelerated wideband perfusion pulse sequence was developed using compressed sensing to sample one arterial input function plane and three myocardial perfusion (MP) planes per heartbeat in patients with a CIED with heart rates as high as 102 beats per minute. Resting perfusion scans were performed in 10 patients with a CIED and in 10 patients with no device as a control group. Two clinical readers compared the resulting images and retrospective images of the 10 patients with a CIED, which were obtained by using a previously described twofold-accelerated wideband perfusion pulse sequence with temporal generalized autocalibrating partially parallel acquisition. Summed visual score (SVS) was defined as the sum of conspicuity, artifact, and noise scores individually ranging from 1 (worst) to 5 (best). Resting MBF in the remote zones was quantified using Fermi deconvolution.
Median SVS was significantly different ( < .05) between the prospective and retrospective CIED groups (13 vs nine) and between the nondevice group and the retrospective CIED group (13.5 vs nine); all median SVSs were nine or greater (clinically acceptable cut point). The median resting MBF in remote zones was not significantly different ( = .27) between patients with a CIED (1.1 mL/min/g; median left ventricular ejection fraction [LVEF], 52.5%) and patients with no device (1.3 mL/min/g; median LVEF, 64.0%). Mean MBF values were consistent with those (mean resting MBF range, 1.0-1.2 mL/min/g) reported by two prior state-of-the-art cardiac perfusion MRI studies.
The proposed scan yielded diagnostically acceptable image quality and enabled reliable quantification of MBF with three MP planes per heartbeat in patients with a CIED with heart rates as high as 102 beats per minute. © RSNA, 2020.
开发一种加速宽带心脏灌注脉冲序列，并测试其能否产生诊断可接受的图像质量，以及能否用于可靠地量化植入心脏电子设备（CIED）患者的心肌血流量（MBF）。
利用压缩感知技术开发了一种五倍加速宽带灌注脉冲序列，用于在心率高达每分钟102次的CIED患者中，每次心跳对一个动脉输入功能平面和三个心肌灌注（MP）平面进行采样。对10例CIED患者和10例无植入设备的患者作为对照组进行静息灌注扫描。两名临床阅片者对10例CIED患者的所得图像与回顾性图像进行比较，回顾性图像是使用先前描述的具有时间广义自校准部分并行采集的两倍加速宽带灌注脉冲序列获得的。总和视觉评分（SVS）定义为分别从1（最差）到5（最佳）的清晰度、伪影和噪声评分之和。使用费米反卷积对远隔区域的静息MBF进行量化。
前瞻性CIED组与回顾性CIED组之间（13比9）以及无设备组与回顾性CIED组之间（13.5比9）的SVS中位数差异有统计学意义（P <.05）；所有SVS中位数均为9或更高（临床可接受切点）。CIED患者（1.1 mL/min/g；左心室射血分数[LVEF]中位数为52.5%）与无植入设备患者（1.3 mL/min/g；LVEF中位数为64.0%）远隔区域的静息MBF中位数差异无统计学意义（P =.27）。平均MBF值与之前两项心脏灌注MRI研究报告的结果（平均静息MBF范围为1.0 - 1.2 mL/min/g）一致。
所提出的扫描方法产生了诊断可接受的图像质量，并能够在心率高达每分钟102次的CIED患者中，每次心跳通过三个MP平面可靠地量化MBF。©RSNA，2020。
