Faculty of Health Sciences, Warsaw School of Engineering and Health, Warsaw, Poland.
Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna near Warsaw, Poland.
Planta Med. 2020 Jul;86(11):732-748. doi: 10.1055/a-1162-9988. Epub 2020 May 18.
The purpose of this review is to summarize current knowledge acquired on preclinical (incision, excision, and dead space wound models) and clinical studies regarding topically used herbal products with wound healing activity. The antimicrobial, anti-inflammatory, and antioxidant mechanisms of their action as well as the adverse effects of herbal therapy will be described. Numerous preclinical and few clinical trials have confirmed the activity of herbal products in the stimulation of wound healing. In contrast to synthetic drugs, for which chemical compositions, purity, efficacy, minimal active concentration, and toxicity are well specified, several herbal formulations require further investigations. Nevertheless, it cannot be precluded that herbal products may be considered as an important support during conventional wound healing therapy or even as synthetic medicament replacements.
本综述旨在总结目前在临床前（切口、切除和死腔伤口模型）和临床研究方面获得的关于具有伤口愈合活性的局部应用草药产品的知识。将描述其作用的抗菌、抗炎和抗氧化机制以及草药治疗的不良反应。大量的临床前研究和少量的临床试验已经证实了草药产品在刺激伤口愈合方面的活性。与化学成分、纯度、功效、最小有效浓度和毒性都得到很好规定的合成药物不同，几种草药配方需要进一步研究。然而，不能排除草药产品可能被认为是常规伤口愈合治疗的重要支持，甚至可能替代合成药物。
