Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Persiaran Setia Murni U13/52, Bandar Setia Alam, Shah Alam 40170, Selangor, Malaysia.
Molecules. 2022 Aug 28;27(17):5541. doi: 10.3390/molecules27175541.
Wound healing is a natural process to restore damaged tissues due to loss of tissue integrity. (locally known as merunggai in Malaysia) has been traditionally used in various ailments, including for wound management. To evaluate the wound healing properties in , publications were searched and selected following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement with predetermined inclusion criteria. The databases searched for primary studies include PubMed, Google Scholar, Science Direct, LILACS, ClinicalTrials.gov, and CENTRAL. In total, 18 in vivo studies were included, which involved the leaves, while the remaining 5 studies involved other plant parts tested on excision, incision, dead space, abrasion, and burn-induced wound models. All studies reported significant wound healing abilities. Most studies used different topical formulations of aqueous leaves extract. The accumulation of collagen content and underlying wound healing mechanism through antimicrobial, antioxidant, and anti-inflammatory activities may be contributed by its bioactive phytochemical content, which has the potential to accelerate the wound contraction, increase the rate of epithelialization, and protect tissues against oxidative damage. In conclusion, showed wound healing potential but further studies are warranted to determine the main bioactive phytocompounds and safety.
伤口愈合是一种由于组织完整性丧失而修复受损组织的自然过程。（在马来西亚当地被称为 merunggai）传统上被用于各种疾病，包括伤口管理。为了评估 的伤口愈合特性，根据系统评价和荟萃分析（PRISMA）声明的指南，按照预先确定的纳入标准，对出版物进行了搜索和选择。用于初级研究的数据库包括 PubMed、Google Scholar、Science Direct、LILACS、ClinicalTrials.gov 和 CENTRAL。总共纳入了 18 项体内研究，其中涉及叶片，而其余 5 项研究涉及其他植物部位，用于切除、切开、死腔、擦伤和烧伤诱导的伤口模型。所有研究均报告了显著的伤口愈合能力。大多数研究使用了不同的水提叶片提取物的局部制剂。其生物活性植物化学物质含量可能通过抗菌、抗氧化和抗炎作用，有助于胶原含量的积累和潜在的伤口愈合机制，从而有可能加速伤口收缩、增加上皮化速率，并保护组织免受氧化损伤。总之， 表现出了伤口愈合的潜力，但需要进一步的研究来确定主要的生物活性植物化合物和安全性。
