Faculdade de Nutrição (FANUT) - Universidade Federal de Alagoas (UFAL), Campus AC Simões, Cidade Universitária, Maceió, Alagoas, Brazil.
Instituto Federal de Alagoas, Alagoas, Brazil.
Nutrition. 2020 Sep;77:110796. doi: 10.1016/j.nut.2020.110796. Epub 2020 Mar 6.
The aim of this study was to evaluate the acute effects of time-restricted feeding in obese women living in social vulnerability who were placed on diets with the same energy deficit.
Fifty-eight obese women (19-44 y of age) were randomized to a group with a hypoenergetic diet and 12 h of fasting daily or to a group with only a hypoenergetic diet for 21 d, with body weight and waist circumference monitoring up to 81 d of intervention. The determination of the individual's energy content of the diets was based on their resting metabolic rate (by indirect calorimetry) and physical activity level (by triaxial accelerometers). Body composition, temperature, blood pressure, appetite, adhesion difficulty, thyroid axis hormones, leptin, glucose concentration, and insulin were measured before and after 21 d of intervention. A mixed analysis of variance test was performed.
The women had a mean age of 31 y and mean body mass index of 33 kg/m². Significant interaction between group × time was observed only in axillary temperature (0.44°C; 95% confidence interval [CI], 0.17-0.74°C; P < 0.01), which increased in the experimental group and in body fat (-0.75%; 95% CI, -1.43% to -0.07%; P = 0.02) decreased in the experimental group. Also, there was a significant decrease in waist circumference in the time-restricted feeding group after 81 d. There were no differences in hormonal profile, resting metabolic rate, reported appetite, or adherence difficulty.
Time-restricted feeding may be considered an alternative strategy for treating obesity in socially vulnerable women.
本研究旨在评估限时进食对处于社会弱势地位并接受相同能量亏空饮食的肥胖女性的急性影响。
将 58 名肥胖女性（年龄 19-44 岁）随机分为每日接受低能量饮食和 12 小时禁食的限时进食组，或仅接受低能量饮食 21 天的对照组，干预期间监测体重和腰围长达 81 天。通过间接测热法确定个体的静息代谢率（RMR）和三轴加速度计确定其体力活动水平，来确定饮食的个体能量含量。在干预前和干预后 21 天，测量身体成分、体温、血压、食欲、黏附困难、甲状腺轴激素、瘦素、血糖浓度和胰岛素。采用混合方差分析检验。
女性的平均年龄为 31 岁，平均体重指数为 33kg/m²。仅观察到组间×时间的交互作用在腋温（0.44°C；95%置信区间 [CI]，0.17-0.74°C；P<0.01），实验组腋温升高，体脂（-0.75%；95% CI，-1.43%至-0.07%；P=0.02）下降。此外，限时进食组在 81 天后腰围显著减小。激素谱、静息代谢率、报告的食欲或黏附困难无差异。
限时进食可能是治疗社会弱势肥胖女性肥胖的一种替代策略。
