Wu Men, Feng Yonghao, Shi Xiaohong
Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Apr 30;13:1429-1434. doi: 10.2147/DMSO.S249232. eCollection 2020.
Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs longer than 200 nucleotides, which are defined as transcripts. The lncRNAs are involved in regulating gene expression at epigenetic, transcriptional, and post-transcriptional levels. Recent studies have found that lncRNA is closely related to many diseases like neurological diseases, endocrine and metabolic disorders. Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus. In this review, we highlight the latest research related to lncRNAs in DPN.
长链非编码RNA（lncRNAs）是一组长度超过200个核苷酸的非编码RNA，被定义为转录本。lncRNAs参与表观遗传、转录和转录后水平的基因表达调控。最近的研究发现，lncRNA与许多疾病密切相关，如神经疾病、内分泌和代谢紊乱。糖尿病周围神经病变（DPN）是糖尿病最常见的慢性并发症之一。在本综述中，我们重点介绍了与DPN中lncRNAs相关的最新研究。
