Nakamura Y, Lathrop M, O'Connell P, Leppert M, Lalouel J M, White R
Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City 84132.
Genomics. 1988 Nov;3(4):342-6. doi: 10.1016/0888-7543(88)90125-5.
A primary genetic linkage map for human chromosome 15 has been constructed from 16 arbitrary DNA markers genotyped in 59 large reference families. The map spans a genetic distance of 146 cM in males and 187 cM in females. The ratio of female/male genetic distance was approximately 2.1 overall within the region of the chromosome covered by our map, but three segments showed a significant male excess in recombination frequency. A subset of seven of the linked markers would be enough to detect linkage of a genetic defect within the mapped region of chromosome 15, if at least 48 phase-known meioses in affected families were available for analysis.
利用在59个大型参考家系中进行基因分型的16个任意DNA标记构建了人类15号染色体的初步遗传连锁图谱。该图谱在男性中的遗传距离为146厘摩，在女性中的遗传距离为187厘摩。在我们图谱覆盖的染色体区域内，女性/男性遗传距离的总体比值约为2.1，但有三个区段在重组频率上显示出明显的男性优势。如果在受影响的家系中有至少48个已知相位的减数分裂可供分析，那么7个连锁标记的一个子集就足以检测15号染色体定位区域内遗传缺陷的连锁情况。
