精神分裂症患者及未受影响的一级亲属的皮质纹状体网络的功能和结构连接之间的关联。
Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.
机构信息
From the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
出版信息
J Psychiatry Neurosci. 2020 Nov 1;45(6):395-405. doi: 10.1503/jpn.190015.
BACKGROUND
Dysfunction of the corticostriatal network has been implicated in the pathophysiology of schizophrenia, but findings are inconsistent within and across imaging modalities. We used multimodal neuroimaging to analyze functional and structural connectivity in the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.
METHODS
We collected resting-state functional magnetic resonance imaging and diffusion tensor imaging scans from people with schizophrenia (n = 47), relatives (n = 30) and controls (n = 49). We compared seed-based functional and structural connectivity across groups within striatal subdivisions defined a priori.
RESULTS
Compared with controls, people with schizophrenia had altered connectivity between the subdivisions and brain regions in the frontal and temporal cortices and thalamus; relatives showed different connectivity between the subdivisions and the right anterior cingulate cortex (ACC) and the left precuneus. Post-hoc t tests revealed that people with schizophrenia had decreased functional connectivity in the ventral loop (ventral striatum-right ACC) and dorsal loop (executive striatum-right ACC and sensorimotor striatum-right ACC), accompanied by decreased structural connectivity; relatives had reduced functional connectivity in the ventral loop and the dorsal loop (right executive striatum-right ACC) and no significant difference in structural connectivity compared with the other groups. Functional connectivity among people with schizophrenia in the bilateral ventral striatum-right ACC was correlated with positive symptom severity.
LIMITATIONS
The number of relatives included was moderate. Striatal subdivisions were defined based on a relatively low threshold, and structural connectivity was measured based on fractional anisotropy alone.
CONCLUSION
Our findings provide insight into the role of hypoconnectivity of the ventral corticostriatal system in people with schizophrenia.
背景
皮质纹状体网络功能障碍与精神分裂症的病理生理学有关，但在影像学模态内和模态间的研究结果并不一致。我们使用多模态神经影像学方法分析了精神分裂症患者及未受影响的一级亲属的皮质纹状体网络的功能和结构连接。
方法
我们收集了精神分裂症患者（n=47）、亲属（n=30）和对照组（n=49）的静息态功能磁共振成像和弥散张量成像扫描。我们在预先定义的纹状体亚区范围内比较了各组之间的基于种子的功能和结构连接。
结果
与对照组相比，精神分裂症患者的纹状体亚区与额、颞皮质和丘脑之间的连接发生了改变；亲属的纹状体亚区与右侧前扣带皮质（ACC）和左侧楔前叶之间的连接不同。事后 t 检验显示，精神分裂症患者的腹侧环路（腹侧纹状体-右侧 ACC）和背侧环路（执行纹状体-右侧 ACC 和感觉运动纹状体-右侧 ACC）的功能连接减弱，同时结构连接也减弱；亲属的腹侧环路和背侧环路（右侧执行纹状体-右侧 ACC）的功能连接减弱，与其他组相比，结构连接没有显著差异。精神分裂症患者双侧腹侧纹状体-右侧 ACC 之间的功能连接与阳性症状严重程度相关。
局限性
纳入的亲属数量适中。纹状体亚区是基于相对较低的阈值定义的，结构连接仅基于各向异性分数来测量。
结论
我们的研究结果提供了皮质纹状体网络中腹侧系统连接减少在精神分裂症患者中的作用的见解。
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