Duarsa Gede Wirya Kusuma, Dau Daniel Oktavianus, Pramana Ida Bagus Putra, Tirtayasa Pande Made Wisnu, Yudiana I Wayan, Santosa Kadek Budi, Oka Anak Agung Gde, Mahadewa Tjokorda Gde Bagus, Ryalino Christopher
Department of Surgery, Faculty of Medicine, Udayana University, Bali, Indonesia.
Department of Anesthesiology, Faculty of Medicine, Udayana University, Bali, Indonesia.
Res Rep Urol. 2020 May 5;12:175-178. doi: 10.2147/RRU.S249734. eCollection 2020.
Many factors could contribute to the cases of residual benign prostate hypertrophy (BPH) volume after transurethral resection of the prostate (TURP), such as age, obesity, testosterone level, and inflammation. The goal of this study was to determine the risk of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β) in prostate tissue, serum prostate-specific antigen (PSA), serum testosterone, and age in promoting prostate volume progression after TURP.
This was a prospective cohort study on 83 BPH patients who underwent TURP at five hospitals in Bali, Indonesia. Trans-rectal ultrasonography (TRUS) was carried out to examine the prostate's size. Three years after, we redo the TRUS examination to collect the data of the latest prostate size. TNF-α, TGF-β, serum PSA, testosterone, and age were registered for analysis. We used Pearson's and Spearman's correlation tests and multivariate analytic linear regression test (coefficient β) by SPSS 13.0 software.
Age, testosterone, PSA, TNF-α, TGF-β were positively correlated to prostate's volume progression. The prostate volume was strongly correlated with age (r= 0.749, <0.001), PSA level (r=0.896, p <0.001), testosterone level (r=0.818, p <0.001), and TGF-β (r=0.609, p <0.001). The TNF-α level has a weak correlation to prostate's volume progression (r=0.392, p <0.001).
TNF-α, TGF-β, PSA, testosterone, and age were significant as the risk factors in promoting the prostate volume progression after TURP.
许多因素可能导致经尿道前列腺电切术（TURP）后残留良性前列腺增生（BPH）体积的情况，如年龄、肥胖、睾酮水平和炎症。本研究的目的是确定前列腺组织中肿瘤坏死因子-α（TNF-α）、转化生长因子-β（TGF-β）、血清前列腺特异性抗原（PSA）、血清睾酮和年龄在TURP后促进前列腺体积进展中的风险。
这是一项对印度尼西亚巴厘岛五家医院接受TURP的83例BPH患者进行的前瞻性队列研究。进行经直肠超声检查（TRUS）以检查前列腺大小。三年后，我们重新进行TRUS检查以收集最新前列腺大小的数据。记录TNF-α、TGF-β、血清PSA、睾酮和年龄进行分析。我们使用SPSS 13.0软件进行Pearson和Spearman相关性检验以及多元分析线性回归检验（系数β）。
年龄、睾酮、PSA、TNF-α、TGF-β与前列腺体积进展呈正相关。前列腺体积与年龄（r = 0.749，p<0.001）、PSA水平（r = 0.896，p<0.001）、睾酮水平（r = 0.818，p<0.001）和TGF-β（r = 0.609，p<0.001）密切相关。TNF-α水平与前列腺体积进展的相关性较弱（r = 0.392，p<0.001）。
TNF-α、TGF-β、PSA、睾酮和年龄是TURP后促进前列腺体积进展的重要危险因素。
