Otolaryngologic Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India.
J Environ Pathol Toxicol Oncol. 2019;38(4):365-375. doi: 10.1615/JEnvironPatholToxicolOncol.2019030997.
Allergic rhinitis is a sensitivity to allergens that causes swelling or puffiness of the nasal airways. The occurrence of allergic rhinitis is mounting worldwide. We examined whether fucoxanthin restrains the development of allergic rhinitis provoked by ovalbumin (OVA). In this study, allergic rhinitis in male BALB/c mice was induced with OVA. The object was to evaluate the effect of fucoxanthin on consequently allergic mice. Allergic responses like rubbing and sneezing were scored to reveal the effect of fucoxanthin in the induced and treated groups. Mean histological scores demonstrated variation in and between OVA-induced and fucoxanthin-treated groups in terms of ciliary loss, eosinophil infiltration, and the like. Lipid profiling (malondialdehyde) confirmed the restraining effect of fucoxanthin on allergic rhinitis. The present study showed that cytokine production, the induction of cell survival molecule NF-κB p65, and subsequent prevention of IκBα phosphorylation are controlled by fucoxanthin, and that interleukins (IL-5, IL-6, and IL-12) support STAT-3 binding to key elements that control IL-17A expression. Additionally, the study showed that interleukin-induced NF-κB and IκBα directly regulate interleukins in collaboration with STAT-3 and related cytokines. Levels of IgE and histamine are the most frequent medications used to treat allergic rhinitis. Considering our findings, we concluded that fucoxanthin represses the development of allergic rhinitis induced by OVA and thus might be a positive drug for its management.
变应性鼻炎是一种对过敏原的敏感性，导致鼻气道肿胀或肿胀。变应性鼻炎的发生在全球范围内不断增加。我们研究了岩藻黄素是否可以抑制卵清蛋白（OVA）引起的变应性鼻炎的发展。在这项研究中，用 OVA 诱导雄性 BALB/c 小鼠的变应性鼻炎。目的是评估岩藻黄素对随后的变应性小鼠的影响。通过评分来评估岩藻黄素在诱导和治疗组中的作用，如揉鼻和打喷嚏等变应性反应。平均组织学评分显示，OVA 诱导组和岩藻黄素治疗组之间在纤毛丧失、嗜酸性粒细胞浸润等方面存在差异。脂质分析（丙二醛）证实了岩藻黄素对变应性鼻炎的抑制作用。本研究表明，细胞因子产生、细胞存活分子 NF-κB p65 的诱导以及随后抑制 IκBα 磷酸化受到岩藻黄素的控制，白细胞介素（IL-5、IL-6 和 IL-12）支持 STAT-3 与控制 IL-17A 表达的关键元素结合。此外，该研究表明，白细胞介素诱导的 NF-κB 和 IκBα 通过与 STAT-3 和相关细胞因子合作，直接调节白细胞介素。IgE 和组胺的水平是治疗变应性鼻炎最常用的药物。考虑到我们的发现，我们得出结论，岩藻黄素抑制 OVA 诱导的变应性鼻炎的发展，因此可能是其管理的一种有效药物。
