Mushtaq Sabha, Dogra Devraj, Dogra Naina, Shapiro Jonathan, Fatema Kaniz, Faizi Nafis, Gupta Gunjan
Department of Dermatology, Government Medical College, Jammu, Jammu and Kashmir, India.
Dermatology Division, Maccabi Healthcare Services, Israel.
Indian Dermatol Online J. 2020 Mar 9;11(2):158-166. doi: 10.4103/idoj.IDOJ_228_19. eCollection 2020 Mar-Apr.
The association between lichen planus (LP) and cardiovascular disease (CVD) risk factors has been demonstrated in previous reports. However, the evidence of CVD risk factors in Indian patients with LP is limited.
To compare CVD risk factors in LP patients and healthy controls.
We performed a cross-sectional study on 122 subjects, 61 LP patients, and 61 controls who visited the outpatient clinic of the dermatology department of a tertiary care hospital. Patients with skin diseases known to be associated with CV risk, pregnant, and lactating women were excluded from the study. CVD risk factors were compared between LP cases and controls using anthropometric measures, hemodynamic and metabolic parameters, and inflammatory marker (ESR).
The proportion of metabolic syndrome (MS) was significantly higher in LP patients than the controls (29.5% vs. 9.8%, odds ratio [OR] 3.83; 95% confidence interval [CI] 1.40-10.50; = 0.006). The proportion of dyslipidemia was also significantly higher in LP patients (70.5% vs. 42.6%; = 0.002). LP patients had a high proportion of obesity ( = 0.004), hypertension ( = 0.004), impaired fasting glucose ( = 0.025), and raised ESR ( = 0.006) as compared to controls. A multivariate regression model demonstrated that dyslipidemia and obesity were significantly associated with LP even after controlling for confounders such as age, gender, sedentarism, dietary habits, alcohol, and impaired fasting glucose. There was no significant association between the extent of LP and the proportion of MS or dyslipidemia.
The present study found a significant association of LP with individual CVD risk factors as well as MS.
既往报道已证实扁平苔藓（LP）与心血管疾病（CVD）危险因素之间存在关联。然而，印度LP患者中CVD危险因素的证据有限。
比较LP患者和健康对照者的CVD危险因素。
我们对122名受试者进行了一项横断面研究，其中61名LP患者和61名对照者，他们均就诊于一家三级护理医院皮肤科门诊。已知与心血管风险相关的皮肤病患者、孕妇和哺乳期妇女被排除在研究之外。使用人体测量指标、血流动力学和代谢参数以及炎症标志物（血沉）比较LP病例组和对照组的CVD危险因素。
LP患者中代谢综合征（MS）的比例显著高于对照组（29.5%对9.8%，比值比[OR]3.83；95%置信区间[CI]1.40 - 10.50；P = 0.006）。LP患者中血脂异常的比例也显著更高（70.5%对42.6%；P = 0.002）。与对照组相比，LP患者肥胖（P = 0.004）、高血压（P = 0.004）、空腹血糖受损（P = 0.025）和血沉升高（P = 0.006）的比例更高。多因素回归模型显示，即使在控制了年龄、性别、久坐不动、饮食习惯、酒精和空腹血糖受损等混杂因素后，血脂异常和肥胖仍与LP显著相关。LP的严重程度与MS或血脂异常的比例之间无显著关联。
本研究发现LP与个体CVD危险因素以及MS之间存在显著关联。
