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形状不规则的氮化铁纳米颗粒作为生物医学应用的潜在候选物：从合成到表征

Irregularly Shaped Iron Nitride Nanoparticles as a Potential Candidate for Biomedical Applications: From Synthesis to Characterization.

作者信息

Wu Kai, Liu Jinming, Saha Renata, Ma Bin, Su Diqing, Peng Chaoyi, Sun Jiajia, Wang Jian-Ping

机构信息

Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Department of Chemical Engineering and Material Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.

出版信息

ACS Omega. 2020 May 13;5(20):11756-11767. doi: 10.1021/acsomega.0c01130. eCollection 2020 May 26.

DOI:10.1021/acsomega.0c01130
PMID:32478267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7254815/
Abstract

Magnetic nanoparticles (MNPs) have been extensively used in drug/gene delivery, hyperthermia therapy, magnetic particle imaging (MPI), magnetic resonance imaging (MRI), magnetic bioassays, and so forth. With proper surface chemical modifications, physicochemically stable and nontoxic MNPs are emerging contrast agents and tracers for MRI and MPI applications. Herein, we report the high magnetic moment, irregularly shaped γ'-FeN nanoparticles for enhanced hyperthermia therapy and T contrast agent for MRI application. The static and dynamic magnetic properties of γ'-FeN nanoparticles are characterized by a vibrating sample magnetometer (VSM) and a magnetic particle spectroscopy (MPS) system, respectively. Compared to the γ-FeO nanoparticles, γ'-FeN nanoparticles show at least three times higher saturation magnetization, which, as a result, gives rise to the stronger dynamic magnetic responses as proved in the MPS measurement results. In addition, γ'-FeN nanoparticles are functionalized with an oleic acid layer by a wet mechanical milling process. The morphologies of as-milled nanoparticles are characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), and nanoparticle tracking analyzer (NTA). We report that with proper surface chemical modification and tuning on morphologies, γ'-FeN nanoparticles could be used as tiny heating sources for hyperthermia and contrast agents for MRI applications with minimum dose.

摘要

磁性纳米颗粒（MNPs）已广泛应用于药物/基因递送、热疗、磁粒子成像（MPI）、磁共振成像（MRI）、磁生物测定等领域。通过适当的表面化学修饰，具有物理化学稳定性且无毒的MNPs正成为用于MRI和MPI应用的造影剂和示踪剂。在此，我们报道了具有高磁矩、形状不规则的γ'-FeN纳米颗粒，用于增强热疗以及作为MRI应用的T造影剂。γ'-FeN纳米颗粒的静态和动态磁性分别通过振动样品磁强计（VSM）和磁粒子光谱（MPS）系统进行表征。与γ-FeO纳米颗粒相比，γ'-FeN纳米颗粒的饱和磁化强度至少高出三倍，因此，如MPS测量结果所示，其产生更强的动态磁响应。此外，通过湿机械研磨工艺用油酸层对γ'-FeN纳米颗粒进行功能化。通过透射电子显微镜（TEM）、动态光散射（DLS）和纳米颗粒跟踪分析仪（NTA）对研磨后的纳米颗粒的形貌进行表征。我们报道，通过适当的表面化学修饰和形貌调控，γ'-FeN纳米颗粒可用作热疗的微小热源以及MRI应用的造影剂，且剂量最小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/7254815/78b74927dd55/ao0c01130_0004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/7254815/6cd5c1695041/ao0c01130_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/7254815/78b74927dd55/ao0c01130_0004.jpg

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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J Am Chem Soc. 2018-8-2

[8]
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[9]
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[10]
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