Yin Xiao-Chun, Li Fang-Ying, He Yu-Feng, Wang Yan, Wang Rong-Min
Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, Institute of Polymer, Northwest Normal University, Lanzhou 730070, China.
Biomater Sci. 2013 May 2;1(5):528-536. doi: 10.1039/c3bm00158j. Epub 2013 Feb 26.
We report the fabrication of keratin films with porosity using keratin, for controlled drug delivery systems. Feathers are currently an important waste product from the poultry industry, however abandoned down products cause an environmentally difficult disposal problem as they are not efficiently extracted and applied. In this paper, feather keratin was extracted using a high-efficiency method. The yield of pure keratin was up to 90%. Its molecular weight was 20 kDa with low dispersity. The films, based on the extracted keratin, were prepared using a simple method, and showed good mechanical properties. Furthermore, the feather keratin films were used to load and release drugs. The resultant feather keratin biopolymer films were pH-responsive and showed controllable drug-release behavior. In summary, we achieved a simple method to reutilize disused feathers. It could be an attractive candidate for applications in the biomedical field.
我们报道了使用角蛋白制备具有孔隙率的角蛋白膜，用于可控药物递送系统。羽毛目前是家禽业的一种重要废品，然而废弃的羽绒产品由于没有得到有效提取和应用，导致了环境处置难题。在本文中，采用高效方法提取了羽毛角蛋白。纯角蛋白的产率高达90%。其分子量为20 kDa，分散度低。基于提取的角蛋白制备的膜采用简单方法，具有良好的机械性能。此外，羽毛角蛋白膜用于药物的负载和释放。所得的羽毛角蛋白生物聚合物膜具有pH响应性，表现出可控的药物释放行为。总之，我们实现了一种重新利用废弃羽毛的简单方法。它可能是生物医学领域应用的一个有吸引力的候选材料。
