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临床试验中分析双歧杆菌 CBA L74 发酵配方对婴儿免疫、微生物群和代谢组成熟的影响。

Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula.

机构信息

Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IRCCS), Milan, Italy.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

出版信息

Nat Commun. 2020 Jun 1;11(1):2703. doi: 10.1038/s41467-020-16582-1.

DOI:10.1038/s41467-020-16582-1
PMID:32483147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7264213/
Abstract

Mother's milk is the best choice for infants nutrition, however when it is not available or insufficient to satisfy the needs of the infant, formula is proposed as an effective substitute. Here, we report the results of a randomized controlled clinical trial (NCT03637894) designed to evaluate the effects of two different dietary regimens (standard formula and Lactobacillus paracasei CBA L74-fermented formula) versus breastfeeding (reference group) on immune defense mechanisms (primary endpoint: secretory IgA, antimicrobial peptides), the microbiota and its metabolome (secondary outcomes), in healthy full term infants according to the type of delivery (n = 13/group). We show that the fermented formula, safe and well tolerated, induces an increase in secretory IgA (but not in antimicrobial peptides) and reduces the diversity of the microbiota, similarly, but not as much as, breastmilk. Metabolome analysis allowed us to distinguish subjects based on their dietary regimen and mode of delivery. Together, these results suggest that a fermented formula favors the maturation of the immune system, microbiota and metabolome.

摘要

母乳是婴儿营养的最佳选择，然而，当母乳无法满足婴儿的需求时，配方奶被提议作为一种有效的替代品。在这里，我们报告了一项随机对照临床试验（NCT03637894）的结果，该试验旨在评估两种不同饮食方案（标准配方和副干酪乳杆菌 CBA L74 发酵配方）与母乳喂养（参考组）对健康足月婴儿免疫防御机制（主要终点：分泌型 IgA、抗菌肽）、微生物组及其代谢组（次要结局）的影响，根据分娩方式（每组 n=13）。我们表明，发酵配方安全且耐受性良好，可诱导分泌型 IgA 增加（但抗菌肽没有增加），并降低微生物组的多样性，与母乳相似，但不如母乳显著。代谢组学分析允许我们根据饮食方案和分娩方式区分受试者。总之，这些结果表明，发酵配方有利于免疫系统、微生物组和代谢组的成熟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/8574cbf1d2ad/41467_2020_16582_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/a7b77d6ead35/41467_2020_16582_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/69a719e718f0/41467_2020_16582_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/d27f2da723ea/41467_2020_16582_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/b6f7c68b38c6/41467_2020_16582_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/8574cbf1d2ad/41467_2020_16582_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/a7b77d6ead35/41467_2020_16582_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/69a719e718f0/41467_2020_16582_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/d27f2da723ea/41467_2020_16582_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/b6f7c68b38c6/41467_2020_16582_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c1/7264213/8574cbf1d2ad/41467_2020_16582_Fig5_HTML.jpg

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