Hegar Badriul, Wibowo Yulianti, Basrowi Ray Wagiu, Ranuh Reza Gunadi, Sudarmo Subianto Marto, Munasir Zakiudin, Atthiyah Alpha Fardah, Widodo Ariani Dewi, Kadim Muzal, Suryawan Ahmad, Diana Ninung Rose, Manoppo Christy, Vandenplas Yvan
Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Nestle Nutrition Institute, Indonesia.
Pediatr Gastroenterol Hepatol Nutr. 2019 Jul;22(4):330-340. doi: 10.5223/pghn.2019.22.4.330. Epub 2019 Jun 25.
Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.
人乳含有众多生物分子。人乳寡糖（HMOs）是母乳中含量第三丰富的成分，仅次于乳糖和脂质。在合成的HMOs中，2'-岩藻糖基乳糖（2'-FL）和乳糖-N-新四糖（LNnT）得到了广泛研究，并被认为对婴儿营养安全。多项研究报告了HMOs的健康益处，包括调节肠道微生物群、对病原体的抗粘附作用、调节肠道上皮细胞反应以及免疫系统发育。HMOs的数量和多样性由母亲的遗传背景（HMO分泌者或非分泌者）决定。非分泌者母亲分泌的HMOs比分泌者母亲少。分泌者母亲母乳喂养下的婴儿比非分泌者母亲母乳喂养下的婴儿获得更多健康益处。总之，在婴儿配方奶粉中添加2'-FL和LNnT是婴儿营养领域一项有前景的创新。
