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脂肪干细胞(ASCs)和基质血管成分(SVF)作为对抗冠状病毒病(COVID-19)的潜在疗法

Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease.

作者信息

Gentile Pietro, Sterodimas Aris

机构信息

1Department of Surgical Science, University of Rome Tor Vergata, Rome, Italy.

2Department of Plastic and Reconstructive Surgery, Metropolitan General Hospital, Athens, Greece.

出版信息

Aging Dis. 2020 May 9;11(3):465-469. doi: 10.14336/AD.2020.0422. eCollection 2020 May.

Abstract

A recent and interesting study reported improved respiratory activity after intravenous administration of mesenchymal stem cells (MSCs) into patients affected by coronavirus disease 2019 (COVID-19). These outcomes displayed that intravenous infiltration of MSCs is a safe and efficacy treatment for COVID-19 pneumonia, a severe acute respiratory illness caused by the coronavirus 2 (SARS-CoV-2). Only 7 patients were treated, but with extraordinary results, opening a new strategy in COVID-19 therapy. Currently, no specific therapies against SARS-CoV-2 are available. The MSCs therapy outcomes reported, are striking, as these cells inhibit the over-activation of the immune system, promoting endogenous repair, by improving the lung microenvironment after the SARS-CoV-2 infection. The MSCs could represent an effective, autologous and safe therapy, and therefore, sharing these published results, here is reported the potential use possibilities in COVID-19 of the most common MSCs represented by Adipose Stem Cells (ASCs).

摘要

最近一项有趣的研究报告称,在对2019冠状病毒病(COVID-19)患者静脉注射间充质干细胞(MSCs)后,其呼吸活动得到改善。这些结果表明,MSCs静脉注入是治疗COVID-19肺炎(一种由冠状病毒2(SARS-CoV-2)引起的严重急性呼吸道疾病)的一种安全有效的治疗方法。仅对7名患者进行了治疗,但取得了非凡的效果,为COVID-19治疗开辟了新策略。目前,尚无针对SARS-CoV-2的特异性疗法。所报告的MSCs治疗结果令人瞩目,因为这些细胞通过改善SARS-CoV-2感染后的肺微环境来抑制免疫系统的过度激活,促进内源性修复。MSCs可能代表一种有效、自体且安全的治疗方法,因此,在此分享这些已发表的结果,报告脂肪干细胞(ASCs)所代表的最常见MSCs在COVID-19中的潜在应用可能性。

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