Chakrabarti Sankha Shubhra, Kaur Upinder, Banerjee Anindita, Ganguly Upasana, Banerjee Tuhina, Saha Sarama, Parashar Gaurav, Prasad Suvarna, Chakrabarti Suddhachitta, Mittal Amit, Agrawal Bimal Kumar, Rawal Ravindra Kumar, Zhao Robert Chunhua, Gambhir Indrajeet Singh, Khanna Rahul, Shetty Ashok K, Jin Kunlin, Chakrabarti Sasanka
1Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
2Department of Pharmacology, All India Institute of Medical Sciences, Gorakhpur, UP, India.
Aging Dis. 2020 May 9;11(3):480-488. doi: 10.14336/AD.2020.0402. eCollection 2020 May.
The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.
持续的冠状病毒（COVID-19）大流行见证了规模难以想象的全球政治应对措施。许多国家实施了封锁措施，要求公民非必要工作不得离开住所。印度政府已采取适当且值得称赞的措施来遏制COVID-19的社区传播。虽然这可能极为有益，但本文探讨了COVID-19在印度影响较小的其他原因。我们分析了印度目前SARS-CoV-2的传播、检测和死亡率模式，重点强调了死亡率作为COVID-19疾病临床相关性指标的重要性。我们还分析了可能减轻COVID-19在印度影响的环境和生物学因素。文中讨论了交叉免疫、先天免疫反应、ACE基因多态性和病毒基因突变的重要性。
