肝脏疾病中的肠道微生物群：我们知道什么，又不知道什么？
Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?
作者信息
Jiang Lu, Schnabl Bernd
机构信息
Department of Medicine, University of California San Diego, La Jolla, California; and Department of Medicine, VA San Diego Healthcare System, San Diego, California.
出版信息
Physiology (Bethesda). 2020 Jul 1;35(4):261-274. doi: 10.1152/physiol.00005.2020.
Abstract
The gut and the liver have a bidirectional communication via the biliary system and the portal vein. The intestinal microbiota and microbial products play an important role for modulating liver diseases such as alcohol-associated liver disease, non-alcoholic fatty liver disease and steatohepatitis, and cholestatic liver diseases. Here, we review the role of the gut microbiota and its products for the pathogenesis and therapy of chronic liver diseases.
摘要
肠道与肝脏通过胆道系统和门静脉进行双向沟通。肠道微生物群及其产物在调节诸如酒精性肝病、非酒精性脂肪性肝病、脂肪性肝炎和胆汁淤积性肝病等肝脏疾病中发挥着重要作用。在此，我们综述肠道微生物群及其产物在慢性肝病发病机制和治疗中的作用。
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