Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Central Research Institute, United Imaging Healthcare, Shanghai, China.
J Magn Reson Imaging. 2020 Aug;52(2):397-406. doi: 10.1002/jmri.27208. Epub 2020 Jun 3.
Chest computed tomography (CT) has shown tremendous clinical potential for screening, diagnosis, and surveillance of COVID-19. However, safety concerns are warranted due to repeated exposure of X-rays over a short period of time. Recent advances in MRI suggested that ultrashort echo time MRI (UTE-MRI) was valuable for pulmonary applications.
To evaluate the effectiveness of UTE-MRI for assessing COVID-19.
Prospective.
In all, 23 patients with COVID-19 and with an average interval of 2.81 days between hospital admission and image examination.
FIELD STRENGTH/SEQUENCE: 3T; Respiratory-gated three-dimensional radial UTE pulse sequence.
Image quality score. Patient- and lesion-based interobserver and intermethod agreement for identifying the representative image findings of COVID-19.
Wilcoxon-rank sum test, Kendall's coefficient of concordance (Kendall's W), intraclass coefficients (ICCs), and weighted kappa statistics.
There was no significant difference between the image quality of CT and UTE-MRI (CT vs. UTE-MRI: 4.3 ± 0.4 vs. 4.0 ± 0.5, P = 0.09). Moreover, both patient- and lesion-based interobserver agreement of CT and UTE-MRI for evaluating the image signs of COVID-19 were determined as excellent (ICC: 0.939-1.000, P < 0.05; Kendall's W: 0.894-1.000, P < 0.05.). In addition, the intermethod agreement of two image modalities for assessing the representative findings of COVID-19 including affected lobes, total severity score, ground glass opacities (GGO), consolidation, GGO with consolidation, the number of crazy paving pattern, and linear opacities, as well as pseudocavity were all determined as substantial or excellent (kappa: 0.649-1.000, P < 0.05; ICC: 0.913-1.000, P < 0.05).
Pulmonary MRI with UTE is valuable for assessing the representative image findings of COVID-19 with a high concordance to CT.
2 TECHNICAL EFFICACY STAGE: 3 J. Magn. Reson. Imaging 2020;52:397-406.
胸部计算机断层扫描（CT）在 COVID-19 的筛查、诊断和监测方面显示出了巨大的临床潜力。然而，由于在短时间内多次接受 X 射线照射，因此有必要关注其安全性。最近的 MRI 进展表明，超短回波时间 MRI（UTE-MRI）对于肺部应用具有重要价值。
评估 UTE-MRI 评估 COVID-19 的有效性。
前瞻性。
共有 23 名 COVID-19 患者，从入院到图像检查的平均间隔为 2.81 天。
磁场强度/序列：3T；呼吸门控三维径向 UTE 脉冲序列。
图像质量评分。患者和病变为基础的观察者间和方法间一致性，用于识别 COVID-19 的代表性图像表现。
Wilcoxon 秩和检验、Kendall 系数（Kendall's W）、组内系数（ICC）和加权 Kappa 统计。
CT 和 UTE-MRI 的图像质量无显著差异（CT 与 UTE-MRI：4.3±0.4 与 4.0±0.5，P=0.09）。此外，CT 和 UTE-MRI 评估 COVID-19 图像征象的患者和病变的观察者间一致性均为优秀（ICC：0.939-1.000，P<0.05；Kendall's W：0.894-1.000，P<0.05）。此外，两种成像方式评估 COVID-19 代表性表现的方法间一致性均为中等或优秀，包括受累肺叶、总严重程度评分、磨玻璃影（GGO）、实变、GGO 伴实变、铺路石征的数量、线性影以及假空洞（kappa：0.649-1.000，P<0.05；ICC：0.913-1.000，P<0.05）。
肺部 UTE-MRI 对评估 COVID-19 的代表性图像表现具有重要价值，与 CT 高度一致。
2 技术功效分期：3 J. Magn. Reson. Imaging 2020；52：397-406。
