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刺孢霉素的研究。II. 刺孢霉素B、C、D、E、F和G的分离与特性

Studies on aculeacin. II. Isolation and characterization of aculeacins B, C, D, E, F and G.

作者信息

Satoi S, Yagi A, Asano K, Mizuno K, Watanabe T

出版信息

J Antibiot (Tokyo). 1977 Apr;30(4):303-7. doi: 10.7164/antibiotics.30.303.

DOI:10.7164/antibiotics.30.303
PMID:863789
Abstract

Six new antibiotics were isolated as the minor components related to aculeacin A from the culture broth of Aspergillus aculeatus M-4214 and named as aculeacins B, C, D, E, F and G. Their physico-chemical properties were analogous to those of aculeacin A and they showed significant activity against fungi. All of the minor components liberated palmitic acid on alkaline hydrolysis. Amino acid analysis showed that threonine and hydroxyproline are common constituents of aculeacins.

摘要

从棘孢曲霉M-4214的培养液中分离出六种新抗生素，它们是与棘霉素A相关的次要成分，分别命名为棘霉素B、C、D、E、F和G。它们的物理化学性质与棘霉素A相似，对真菌显示出显著活性。所有次要成分在碱性水解时均释放出棕榈酸。氨基酸分析表明，苏氨酸和羟脯氨酸是棘霉素的常见组成成分。

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