Department of Radiation and Medical Oncology, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Gynaecology, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Crit Rev Oncol Hematol. 2020 Aug;152:102985. doi: 10.1016/j.critrevonc.2020.102985. Epub 2020 May 24.
Cervical cancer is the most commonly diagnosed cancer among women. Early diagnosis and prediction will greatly improve the treatment outcome. Many clinical parameters have been used as diagnostic and prognostic factors for cervical cancer patients, including tumor stage, histological type, lymph node status, but with limitations in prediction accuracy. The development of noninvasive biomarker with the potential to provide more specific tumor characterization before treatment begins or during therapy is urgent needed, which may permit clinicians to administer a more individualized anti-cancer treatment. Radiomics is a mathematical-statistical procedure extracting information from medial images, which has the potential for prediction of staging, histological type, node status, relapse and survival in patients with cervical cancer. In this manuscript, we reviewed recent clinical studies and future potential for the application of radiomics in the treatment of patients with cervical cancer, and discussed the current challenges and limitations of radiomics for oncology.
宫颈癌是女性最常见的癌症。早期诊断和预测将极大地改善治疗效果。许多临床参数已被用作宫颈癌患者的诊断和预后因素,包括肿瘤分期、组织学类型、淋巴结状态,但在预测准确性方面存在局限性。因此,迫切需要开发具有在治疗前或治疗期间提供更具体肿瘤特征潜力的非侵入性生物标志物,这可能使临床医生能够实施更个体化的抗癌治疗。放射组学是一种从医学图像中提取信息的数学统计过程,有可能预测宫颈癌患者的分期、组织学类型、淋巴结状态、复发和生存。在本文中,我们综述了放射组学在宫颈癌治疗中的最新临床研究及未来应用潜力,并讨论了放射组学在肿瘤学中的当前挑战和局限性。