妇科癌症幸存者中身体活动、神经病变症状与健康相关生活质量之间的关联。
The associations between physical activity, neuropathy symptoms and health-related quality of life among gynecologic cancer survivors.
机构信息
University of Minnesota, Division of Gynecologic Oncology, Minneapolis, MN, United States of America.
University of Minnesota, Division of Hematology and Oncology, Minneapolis, MN, United States of America.
出版信息
Gynecol Oncol. 2020 Aug;158(2):361-365. doi: 10.1016/j.ygyno.2020.05.026. Epub 2020 Jun 1.
OBJECTIVE
Physical activity may mitigate the effects of cancer treatment. We sought to evaluate the association between self-reported physical activity, neuropathy symptomatology, and emotional health in gynecologic cancer survivors.
METHODS
Patients were recruited from an academic gynecologic oncology practice to a prospective cohort study. Participants completed semiannual surveys on quality of life (QOL), neuropathy symptoms, depression, distress, and health behaviors. Abstracted clinical data included cancer type, FIGO stage at diagnosis and treatments received (chemotherapy, surgery, radiation). Physical activity [no: moderate physical activity <150 min/week, yes: ≥150 min/week] and neuropathy symptomatology [high (FACT/GOG-Ntx ≥11; upper quartile); low (<11)] were dichotomized. Linear regression models assessed the associations between physical activity, neuropathy and psychosocial outcomes.
RESULTS
A total of 194 participants were included in this analysis. We identified significant interactions between physical activity and neuropathy in the depression (p = 0.0006) and QOL (p = 0.007) models. Greater physical activity and lower neuropathy scores were independently associated with fewer depressive symptoms (p = 0.02 and p < 0.0001, respectively) and greater QOL (p = 0.005 and p < 0.0001). Low neuropathy scores were associated with lower distress (p < 0.0001). Women with high neuropathy scores had larger beneficial associations between being physically active and depression and QOL. In the distress model, interaction between neuropathy and physical activity was suggested (p = 0.05).
CONCLUSIONS
Physical activity was associated with favorable psychosocial outcomes in gynecologic cancer survivors, most notably among those with worse neuropathy. These data suggest prescriptive exercise should be evaluated as a means of mitigating cancer-associated neuropathies and their effect on emotional health.
目的
身体活动可能减轻癌症治疗的影响。我们旨在评估妇科癌症幸存者自我报告的身体活动、周围神经病变症状和情绪健康之间的关系。
方法
从学术妇科肿瘤学实践中招募患者参加前瞻性队列研究。参与者每半年完成一次关于生活质量（QOL）、周围神经病变症状、抑郁、痛苦和健康行为的调查。提取的临床数据包括癌症类型、诊断时的 FIGO 分期和接受的治疗（化疗、手术、放疗）。身体活动[否：中度身体活动<150 分钟/周，是：≥150 分钟/周]和周围神经病变症状[高（FACT/GOG-Ntx≥11；上四分位数）；低（<11）]均分为二分类。线性回归模型评估了身体活动、周围神经病变与心理社会结局之间的关系。
结果
共有 194 名参与者纳入本分析。我们发现身体活动与抑郁（p=0.0006）和 QOL（p=0.007）模型中的周围神经病变之间存在显著交互作用。更多的身体活动和较低的周围神经病变评分与较少的抑郁症状独立相关（p=0.02 和 p<0.0001），并且 QOL 更高（p=0.005 和 p<0.0001）。较低的周围神经病变评分与较低的痛苦相关（p<0.0001）。周围神经病变评分较高的女性，在身体活动与抑郁和 QOL 之间具有更大的有益关联。在痛苦模型中，提示周围神经病变和身体活动之间存在交互作用（p=0.05）。
结论
身体活动与妇科癌症幸存者的心理社会结局相关，尤其是在周围神经病变更严重的患者中。这些数据表明，应评估规范性运动作为减轻癌症相关周围神经病变及其对情绪健康影响的一种手段。
Zotero 插件