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自我护理维持、自我护理监测和自我护理管理如何影响2型糖尿病成人患者的糖化血红蛋白?一项多中心观察性研究。

How do self-care maintenance, self-care monitoring, and self-care management affect glycated haemoglobin in adults with type 2 diabetes? A multicentre observational study.

作者信息

Fabrizi Diletta, Rebora Paola, Luciani Michela, Di Mauro Stefania, Valsecchi Maria Grazia, Ausili Davide

机构信息

Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.

Bicocca Bioinformatics Biostatistics And Bioimaging Centre-B4, Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.

出版信息

Endocrine. 2020 Sep;69(3):542-552. doi: 10.1007/s12020-020-02354-w. Epub 2020 Jun 5.

Abstract

PURPOSE

To evaluate how self-care maintenance, self-care monitoring, and self-care management affect glycated haemoglobin in type 2 diabetes mellitus patients and to set cut-off points of the Self-Care of Diabetes Inventory scales using glycated haemoglobin as outcome of interest.

METHODS

A secondary analysis of a previous multicentre observational cross-sectional study was conducted. Overall, 540 adults with type 2 diabetes mellitus confirmed diagnosis were involved. Socio-demographic and clinical data were collected. Self-care maintenance, self-care monitoring, and self-care management were measured by the Self-Care of Diabetes Inventory. Linear regression models were performed to assess the relationship between self-care maintenance, self-care monitoring, and self-care management and glycated haemoglobin. Receiver operating characteristics curves were carried out to identify the best cut-off score for each self-care scale considering glycated haemoglobin >7% as outcome of interest.

RESULTS

Self-care monitoring and self-care management were associated to glycated haemoglobin in both patients without (self-care monitoring p = 0.0008; self-care management p = 0.0178) and with insulin therapy (self-care monitoring p = 0.0007; self-care management p = 0.0224). Self-care maintenance was associated to glycated haemoglobin in patients without insulin therapy (p = 0.0118). Cut-off scores providing the best performance were 70 points for self-care maintenance and self-care monitoring, and 60 points for self-care management.

CONCLUSIONS

Self-care maintenance, self-care monitoring, and self-care management differently affect glycated haemoglobin in patients with type 2 diabetes mellitus. Clinicians could implement tailored interventions to improve glycaemic control considering the lacking area of self-care.

摘要

目的

评估自我护理维持、自我护理监测和自我护理管理如何影响2型糖尿病患者的糖化血红蛋白,并以糖化血红蛋白作为感兴趣的结果来设定糖尿病自我护理量表的截断点。

方法

对之前一项多中心观察性横断面研究进行二次分析。总共纳入了540名确诊为2型糖尿病的成年人。收集了社会人口学和临床数据。通过糖尿病自我护理量表来测量自我护理维持、自我护理监测和自我护理管理。采用线性回归模型评估自我护理维持、自我护理监测和自我护理管理与糖化血红蛋白之间的关系。绘制受试者工作特征曲线,以糖化血红蛋白>7%作为感兴趣的结果,确定每个自我护理量表的最佳截断分数。

结果

在未接受胰岛素治疗的患者(自我护理监测p = 0.0008;自我护理管理p = 0.0178)和接受胰岛素治疗的患者(自我护理监测p = 0.0007;自我护理管理p = 0.0224)中,自我护理监测和自我护理管理均与糖化血红蛋白相关。在未接受胰岛素治疗的患者中,自我护理维持与糖化血红蛋白相关(p = 0.0118)。自我护理维持和自我护理监测的最佳表现截断分数为70分,自我护理管理的最佳表现截断分数为60分。

结论

自我护理维持、自我护理监测和自我护理管理对2型糖尿病患者的糖化血红蛋白有不同影响。临床医生可考虑自我护理的欠缺领域实施针对性干预措施以改善血糖控制。

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