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COVID-19:固有免疫与适应性免疫之间的桥梁缺失?

COVID-19: Loss of bridging between innate and adaptive immunity?

机构信息

Department of Head and Neck Oncology, HCG Cancer Hospital, Bengaluru, Karnataka, India.

Department of Head and Neck Oncology, HCG Cancer Hospital, Bengaluru, Karnataka, India.

出版信息

Med Hypotheses. 2020 Nov;144:109861. doi: 10.1016/j.mehy.2020.109861. Epub 2020 May 23.

DOI:10.1016/j.mehy.2020.109861
PMID:32505066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7245229/
Abstract

COVID-19 has spread to most countries in the world. However, there are some striking differences in how COVID-19 is behaving in different age groups. While data on COVID-19 is limited, children appear to be less susceptible to severe disease. These unique characteristics may be considered as a potential link to understanding the immune system and response in COVID-19 and lead to an effective cure to the disease. We suggest a possible role of loss of bridging between innate and adaptive immunity in COVID-19 and a potential treatment modality also discussed.

摘要

COVID-19 已蔓延至世界上大多数国家。然而,COVID-19 在不同年龄组的表现存在一些显著差异。虽然 COVID-19 的相关数据有限,但儿童似乎不易患重病。这些独特的特征可能被认为是理解 COVID-19 中免疫系统和反应的潜在联系,并导致该疾病的有效治愈方法。我们提出了 COVID-19 中先天免疫和适应性免疫之间桥梁缺失的可能作用,并讨论了一种潜在的治疗方式。

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