Faculty of Medicine, University Clinic for Dermatology, Ss. Cyril and Methodius University, Skopje, Macedonia.
Dermatol Ther. 2020 Jul;33(4):e13780. doi: 10.1111/dth.13780. Epub 2020 Jul 3.
The epidemiological burden of COVID-19 is a healthcare challenge throughout the world, not only in terms of testing the limits of medical capacities, but also as an enigma considering preventive strategies and methods. The upper respiratory tract mucosa is the first line of defense, as a physical barrier, as well as through multiple innate and adaptive immune mechanisms which are crucial for efficient antiviral responses. Identifying methods able to reduce or prevent colonization, viral adhesion, and promote virus shedding on mucous membranes or have the ability to inactivate pathogens and thus reduce virus dose and/or increase immune response would be essential in the management of COVID-19 outbreak and help in flattening the curve. We review the effects of propolis, an old remedy with proven antiviral properties, as a possible low-cost inhibitor of SARS-CoV-2 in the oropharyngeal niche, prophylaxis, or adjuvant therapy.
COVID-19 的流行病学负担是全球范围内的医疗保健挑战，不仅在测试医疗能力的极限方面，而且在考虑预防策略和方法方面也是一个谜。上呼吸道黏膜是第一道防线，既是物理屏障，也是通过多种先天和适应性免疫机制发挥作用，这些机制对有效的抗病毒反应至关重要。确定能够减少或预防定植、病毒黏附以及促进黏膜上病毒脱落的方法，或者具有灭活病原体的能力，从而减少病毒剂量和/或增强免疫反应的方法，对于 COVID-19 爆发的管理至关重要，并有助于减缓曲线上升。我们回顾了蜂胶的作用，蜂胶是一种具有经过验证的抗病毒特性的古老药物，作为一种可能的低成本 SARS-CoV-2 在上呼吸道龛中的抑制剂，用于预防或辅助治疗。
