Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, United States.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, United States.
Ultrasonics. 2020 Dec;108:106200. doi: 10.1016/j.ultras.2020.106200. Epub 2020 Jun 2.
The ability to assess likelihood of plaque rupture can determine the course of treatment in coronary artery disease. One indicator of plaque vulnerability is the development of blood vessels within the plaque, or intraplaque neovascularization. In order to visualize these vessels with increased sensitivity in the cardiac catheterization lab, a new approach for imaging blood flow in small vessels using side-viewing intravascular ultrasound (IVUS) is proposed. This approach based on compounding adjacent angular acquisitions was evaluated in tissue mimicking phantoms and ex vivo vessels. In phantom studies, the Doppler CNR increased from 3.3 ± 1.0 to 13 ± 2.6 (conventional clutter filtering) and from 1.9 ± 0.15 to 7.5 ± 1.1 (SVD filtering) as a result of applying angular compounding. When imaging flow at a rate of 5.6 mm/s in 200 µm tubes adjacent to the lumen of ex vivo porcine arteries, the Doppler CNR increased from 5.3 ± 0.95 to 7.2 ± 1.3 (conventional filtering) and from 23 ± 3.3 to 32 ± 6.7 (SVD filtering). Applying these strategies could allow increased sensitivity to slow flow in side-viewing intravascular ultrasound imaging.
评估斑块破裂可能性的能力可以确定冠状动脉疾病的治疗过程。斑块易损性的一个指标是斑块内血管的发育，即斑块内新生血管形成。为了在心脏导管实验室中更敏感地可视化这些血管，提出了一种使用侧视血管内超声 (IVUS) 对小血管血流进行成像的新方法。该方法基于相邻角采集的复合，在组织模拟体模和离体血管中进行了评估。在体模研究中，由于应用了角度复合，多普勒 CNR 从 3.3 ± 1.0 增加到 13 ± 2.6（常规杂波滤波）和从 1.9 ± 0.15 增加到 7.5 ± 1.1（SVD 滤波）。当以 5.6mm/s 的速度在离体猪动脉管腔旁边的 200µm 管中成像时，多普勒 CNR 从 5.3 ± 0.95 增加到 7.2 ± 1.3（常规滤波）和从 23 ± 3.3 增加到 32 ± 6.7（SVD 滤波）。应用这些策略可以提高侧视血管内超声成像中对缓慢血流的敏感性。
