Department of Prosthodontics, School and Hospital of Stomatology, Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun, 130021, China.
Department of Oral Implantology, School of Medicine, Ninth People's Hospital Affiliated with Shanghai Jiao Tong University, Shanghai, China.
Biomed Pharmacother. 2020 Aug;128:110372. doi: 10.1016/j.biopha.2020.110372. Epub 2020 Jun 7.
The heavy burden of oral diseases such as oral cancers, dental caries, periodontitis, etc. and their consequence on the patient's quality of life demonstrated an urgent demand for developing effective therapeutics. Quercetin as a natural derived flavonoid, could be utilized in the therapeutic formulation of various diseases such as diabetes, breast cancer and asthma, owing to its prominent pharmacological values. In the last decade, the applications of quercetin as a natural compound in oral treatment have attracted increasing interest due to its multifunction including antioxidant, antibacterial, anti-inflammatory and antineoplastic activities. Besides, considering the low bioavailability of quercetin, great efforts have been made in its drug delivery systems to address the problem of limited application. Therefore, this review summarized the cutting-edge researches on versatile effects and enhanced bioavailability of quercetin resulting from innovative drug delivery systems, particularly focused on its potential against oral diseases. The application of quercetin would provide novel and promising therapeutic approach for clinical treatment, promoting the development of global dental public health.
口腔疾病（如口腔癌、龋齿、牙周炎等）及其对患者生活质量的影响负担沉重，这表明人们迫切需要开发有效的治疗方法。槲皮素作为一种天然衍生的类黄酮，由于其显著的药理学价值，可用于治疗糖尿病、乳腺癌和哮喘等各种疾病的药物制剂。在过去的十年中，由于其抗氧化、抗菌、抗炎和抗肿瘤活性等多种功能，槲皮素作为一种天然化合物在口腔治疗中的应用引起了越来越多的关注。此外，考虑到槲皮素的生物利用度较低，人们在其药物传递系统方面做出了巨大努力，以解决其应用受限的问题。因此，本综述总结了创新药物传递系统赋予槲皮素的多效性和增强的生物利用度的最新研究，特别是其在防治口腔疾病方面的潜在应用。槲皮素的应用将为临床治疗提供新的、有前途的治疗方法，促进全球口腔公共卫生事业的发展。
