Nigatie Marye, Melak Tadele, Asmelash Daniel, Worede Abebaw
Department of Medical Laboratory Science, College of medicine and Health Science, Woldia University, Woldia, Ethiopia.
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
J Multidiscip Healthc. 2022 Jul 15;15:1481-1491. doi: 10.2147/JMDH.S368832. eCollection 2022.
Dyslipidemia refers to a lipid profile disturbance due to decreased high-density lipoprotein cholesterol and elevated low-density lipoprotein cholesterol, triglycerides, and total cholesterol. infection can lead to some appetite-related disorders that may cause deregulated absorption of nutrients in the digestive system, contributing to changes in serum lipids. The purpose of this study is to assess dyslipidemia and its associated factors among -infected patients attending at University of Gondar Comprehensive Specialized Hospital.
A comparative cross-sectional study was conducted on 231 -positive and control groups, which were included by the convenience sampling technique from March to May 2021 at University of Gondar Specialized Hospital. Sociodemographic and behavioral characteristic data were collected using a pretested questionnaire, and 5mL of venous blood were used to determine the lipid profiles using DxC 700 AU chemistry analyzer. The data were analyzed using SPSS version 25. Mann-Whitney -test and multivariable logistic regression were applied, and P-value <0.05 is considered statistically significant.
The magnitude of dyslipidemia among -infected patients was 71.8% (95% CI: 62.7-79.7). There was a statistically significant difference in lipid profiles between -infected patients and control groups. The median (IQR) of lipid profiles in -infected patients and control groups were for low-density lipoprotein: 108 (89.8, 145.5) vs 95 (79.45, 115.8, P<0.001), for triglycerides: 93 (65,117) vs 83 (58.5, 102, P=0.031), and cholesterol: 143 (119.5, 169,) vs 125 (110,143, P<0.001) mg/dl, respectively. infection, alcohol drinking, unable to read and write, primary school, and secondary school were a significant associated variables with dyslipidemia (P<0.05).
There was a median lipid profile statistically significant difference between -positive and control groups. infection, educational status, and alcohol drinking habit had statistically significant association with dyslipidemia.
血脂异常是指由于高密度脂蛋白胆固醇降低以及低密度脂蛋白胆固醇、甘油三酯和总胆固醇升高导致的血脂谱紊乱。感染可导致一些与食欲相关的紊乱，这可能会引起消化系统营养物质吸收失调，从而导致血脂变化。本研究的目的是评估贡德尔大学综合专科医院就诊的感染患者中的血脂异常及其相关因素。
于2021年3月至5月在贡德尔大学专科医院采用方便抽样技术对231名感染阳性患者和对照组进行了一项比较横断面研究。使用预先测试的问卷收集社会人口学和行为特征数据，并采集5毫升静脉血，使用DxC 700 AU化学分析仪测定血脂谱。数据使用SPSS 25版进行分析。应用曼-惠特尼U检验和多变量逻辑回归，P值<0.05被认为具有统计学意义。
感染患者中血脂异常的发生率为71.8%（95%CI：62.7 - 79.7）。感染患者与对照组之间的血脂谱存在统计学显著差异。感染患者和对照组血脂谱的中位数（IQR）分别为：低密度脂蛋白：108（89.8，145.5）与95（79.45，115.8，P<0.001）；甘油三酯：93（65，117）与83（58.5，102，P = 0.031）；胆固醇：143（119.5，169）与125（110，143，P<0.001）mg/dl。感染、饮酒、无法读写、小学学历和初中学历是与血脂异常显著相关的变量（P<0.05）。
感染阳性组与对照组之间血脂谱中位数存在统计学显著差异。感染、教育程度和饮酒习惯与血脂异常存在统计学显著关联。
