Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
BMC Psychiatry. 2020 Jun 16;20(1):307. doi: 10.1186/s12888-020-02698-7.
The Binge Eating Genetics Initiative (BEGIN) is a multipronged investigation examining the interplay of genomic, gut microbiota, and behavioral factors in bulimia nervosa and binge-eating disorder.
1000 individuals who meet current diagnostic criteria for bulimia nervosa or binge-eating disorder are being recruited to collect saliva samples for genotyping, fecal sampling for microbiota characterization, and recording of 30 days of passive data and behavioral phenotyping related to eating disorders using the app Recovery Record adapted for the Apple Watch.
BEGIN examines the interplay of genomic, gut microbiota, and behavioral factors to explore etiology and develop predictors of risk, course of illness, and response to treatment in bulimia nervosa and binge-eating disorder. We will optimize the richness and longitudinal structure of deep passive and active phenotypic data to lay the foundation for a personalized precision medicine approach enabling just-in-time interventions that will allow individuals to disrupt eating disorder behaviors in real time before they occur.
The ClinicalTrials.gov identifier is NCT04162574. November 14, 2019, Retrospectively Registered.
暴食遗传学倡议（BEGIN）是一项多方面的研究，旨在检查暴食症和暴食障碍中基因组、肠道微生物群和行为因素的相互作用。
正在招募 1000 名符合暴食症或暴食障碍现行诊断标准的个体，以收集唾液样本进行基因分型、粪便样本进行微生物群特征分析，并使用专为 Apple Watch 设计的应用程序 Recovery Record 记录与饮食失调相关的 30 天被动数据和行为表型。
BEGIN 研究了基因组、肠道微生物群和行为因素的相互作用，以探索暴食症和暴食障碍的病因，并开发风险、疾病进程和治疗反应的预测因子。我们将优化深度被动和主动表型数据的丰富度和纵向结构，为个性化精准医疗方法奠定基础，实现实时干预，使个体能够在暴食行为发生之前实时中断。
ClinicalTrials.gov 标识符为 NCT04162574。2019 年 11 月 14 日，回顾性注册。
