Ghasemipour N, Goudarzi H, Banani M, Asasi K
Department of Clinical Sciences, Poultry Diseases Research Center, Veterinary School of Shiraz University, Shiraz, Iran.
Department of Avian Diseases Research and Diagnosis, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.
Vet World. 2019 Apr;13(4):655-660. doi: 10.14202/vetworld.2020.655-660. Epub 2020 Apr 12.
The best strategy to prevent or control an (ORT) infection is vaccination. The present study aimed to compare the efficacy of the first Iranian inactivated ORT vaccine (Razi, Iran), which had been prepared from a native strain, with the Nobilis ORT Inac (Intervet, The Netherlands) through a challenge trial.
Seventy-two 1-day-old specific pathogen-free White Leghorn chickens were used in this study. The birds were divided randomly into four groups. Following the vaccination and challenge of the birds, the efficacy of the Razi and the Intervet ORT vaccines was evaluated by serological, bacteriological, and molecular methods.
The antibody titer in vaccinated groups was determined to be significantly higher than unvaccinated birds. In addition, the difference in postmortem lesion scores between the vaccinated and unvaccinated birds was significant. The differences in the means of the antibody titers and postmortem lesion scores in birds that were vaccinated by the Razi and Intervet ORT vaccines were not significant.
Considering the results of this study, it can be concluded that the Iranian native ORT vaccine was comparable to the Intervet vaccine. The Razi ORT vaccine has effectively decreased the duration of the ORT infection and can effectively protect the chickens against an ORT infection.
预防或控制禽网状内皮组织增殖症（ORT）感染的最佳策略是接种疫苗。本研究旨在通过攻毒试验比较由本地菌株制备的伊朗首款灭活ORT疫苗（伊朗拉齐疫苗）与诺比里斯ORT灭活疫苗（荷兰英特威公司生产）的效果。
本研究使用了72只1日龄无特定病原体的白来航鸡。这些鸡被随机分为四组。在对鸡进行疫苗接种和攻毒后，通过血清学、细菌学和分子学方法评估拉齐疫苗和英特威ORT疫苗的效果。
接种疫苗组的抗体滴度明显高于未接种疫苗的鸡。此外，接种疫苗和未接种疫苗的鸡在死后病变评分上的差异显著。用拉齐疫苗和英特威ORT疫苗接种的鸡在抗体滴度平均值和死后病变评分上的差异不显著。
考虑到本研究结果，可以得出结论，伊朗本土ORT疫苗与英特威疫苗相当。拉齐ORT疫苗有效缩短了ORT感染的持续时间，并能有效保护鸡免受ORT感染。
