Cao Y, Cai K, Xiong L
Acta Virol. 2020;64(2):245-250. doi: 10.4149/av_2020_201.
An outbreak of new severe acute respiratory syndrome coronavirus disease, coronavirus disease 2019 (COVID-19), has emerged during December 2019. The ongoing outbreak in Wuhan City spread rapidly throughout China, where the fatality rate ranged from 2.1 to 4.9%. Due to its high transmissibility, the World Health Organization (WHO) declared a public health emergency of international concern on 30 January 2020. The current outbreak has the potential to become the first pandemic of the new millennium. Most patients who were first diagnosed with COVID-19 worked at or lived in the vicinity of the local Huanan Seafood Wholesale Market, where live animals were also on sale. The concerted efforts of Chinese scientists led to the independent isolation from patients and identification of a novel coronavirus, SARS coronavirus 2 (SARS-CoV-2), on 6 January 2020; this has been an important step in the development of treatment. The purpose of this article is to overview the history, epidemiology, clinical characteristics, diagnosis, and treatment of COVID 2019 reported in recently published studies. Based on the results of virus genome sequencing and a model of the interaction between host cells and the virus, we propose several possible targets for antiviral drugs, which may provide new ideas for epidemic control and vaccine development. Keywords: 2019 novel coronavirus; pneumonia; SARS-CoV-2; Coronaviridae; COVID-19.
2019年12月期间，一种新型严重急性呼吸综合征冠状病毒疾病，即2019冠状病毒病（COVID-19）爆发。武汉市持续的疫情迅速蔓延至中国各地，病死率在2.1%至4.9%之间。由于其高传播性，世界卫生组织（WHO）于2020年1月30日宣布这是一场国际关注的突发公共卫生事件。当前的疫情有可能成为新千年的第一场大流行。大多数最初被诊断为COVID-19的患者在当地华南海鲜批发市场工作或居住在其附近，该市场也有活体动物出售。中国科学家共同努力，于2020年1月6日从患者身上独立分离并鉴定出一种新型冠状病毒，即严重急性呼吸综合征冠状病毒2（SARS-CoV-2）；这是治疗进展中的重要一步。本文的目的是概述近期发表的研究中报道的COVID-19的历史、流行病学、临床特征、诊断和治疗。基于病毒基因组测序结果以及宿主细胞与病毒相互作用的模型，我们提出了几种抗病毒药物的可能靶点，这可能为疫情控制和疫苗研发提供新思路。关键词：2019新型冠状病毒；肺炎；SARS-CoV-2；冠状病毒科；COVID-19。
