Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Int J Infect Dis. 2020 Aug;97:371-373. doi: 10.1016/j.ijid.2020.06.014. Epub 2020 Jun 14.
Recently, an increasing number of SARS-CoV-2 patients with COVID-19 syndrome, which overlaps with Kawasaki Disease (KD), have been reported, supporting the suggestion that infection is one of the triggers of KD. We summarized the reports of simultaneous familial KD cases to better understand the etiopathogenesis of both KD and Multisystem Inflammatory Syndrome in Children (MIS-C) related to COVID-19. Here we discuss the etiology of these syndromes from the point of view of infection and genetic susceptibility.
最近，越来越多的 COVID-19 综合征合并川崎病（KD）的 SARS-CoV-2 患者被报道，这支持了感染是 KD 的触发因素之一的说法。我们总结了同时发生的家族性 KD 病例报告，以更好地了解 COVID-19 相关的 KD 和儿童多系统炎症综合征（MIS-C）的发病机制。在这里，我们从感染和遗传易感性的角度讨论这些综合征的病因。
